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LIPOGRANULOMA (lipogranuloma; Greek lipos fat + lat. granulum kernel + oma; synonym: injection lipogranuloma, lipofagalny granuloma, paraffinoma, oleoma) — center of chronic inflammations , developing as a result of parenteral administration of oily substances or in a zone of a necrosis of fatty tissue. L. arises at injections of oil solutions of medicines (camphor, biokhinol), long inhalation of oily substances, in sites of a bruise and crush of a fatty tissue. At some inf. diseases (e.g., sapropyra) L. it is formed owing to toxic or allergic defeats. Injection dermonecrotic L. («a spray disease») develops as a result of hypodermic introduction to lay down. and preventive drugs (antibiotics, a diphtherial anatoxin, etc.), arises at children more often that some authors explain with special vulnerability of hypodermic cellulose at children's age.

Microscopic picture of a liiogranulema: 1 — fatty cysts; 2 — huge multinucleate cells (lipophages).

Morfol, lines of inflammatory reaction are universal and do not depend on an injection site and the nature of oily substance. In all cases of L. — it is the center hron, inflammations, feature to-rogo are the small cysts covered by large cells of epithelioid type and containing fatty masses (fig., 1). Between cavities infiltration of fabric is observed by various elements of a granulyatsionny row among which colossal multi-core cells — lipophages are found (fig., 2). In infiltrate the educations on a structure reminding tubercular hillocks quite often meet. In the center dermonecrotic L. the unstructured mass of the breaking-up fibrous and fatty tissue which can break outside with formation of fistulas are visible.

Wedge, picture L. it is characterized by development of the dense infiltrate in hypodermic cellulose covered, as a rule, with not changed skin. At a palpation of L. it is a little painful, the zybleniye is sometimes noted. During the progressing of a disease surrounding fabrics are involved in process. Self-healing is observed extremely seldom. Treatment is operational, with radical excision of the struck fabrics.

Bibliography: The multivolume guide to pathological anatomy, under the editorship of A. I. Strukov, t. 1, page 291, M., 1963; Rapoport Ya. L., etc. Pathology of injection defeats of soft tissues, injection dermo-and liponekrotichesky granuloma, Arkh. patol., t. 18, No. 7, page 117, 1956; Lever W. F. a.Schaumburg-Lever G. Histopathology of the skin, Philadelphia — Toronto, 1975; R o b-b i n s S. L. R. Pathologic basis of disease, p. 83, Philadelphia a. o., 1974.

G. M. Mogilevsky.