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EPITHELIAL CELLS (Greek epi-on, atop + Greek thele of pacifiers + eidos a look) — the phagocytes of a monocyte of a rny origin which are taking part in formation of granulomas. AA. to. have ability to phagocytosis, the bactericidal and synthesizing properties.

The epithelial cell is formed of a macrophage and in the formation there pass two stages — unripe and mature E. to. Mature E. to. are transformed to colossal cells of foreign bodys (see. Colossal cells) and colossal cells of Pirogov — Langkhansa (see Tuberculosis). Term of life E. to. — 3 — 4 weeks, colossal cells — several days.

AA. to. have eosinophilic cytoplasm, a big kernel poor in chromatin and a large kernel. In their cytoplasm there are a lot of mitochondrions and lysosomes, the cytoplasmic reticulum and a lamellar complex are well developed. Structure E. to. changes depending on an orientation of their function.

Education E. to. and their transformation reflect kinetics of a granulomatosis: formation mature (macrophagic), an epita lioidno-kletoch-ache also giant-cell granulomas

(see). The possibility of a granulomatosis is defined by three conditions: availability of the substances capable to stimulate maturing of macrophages and their transformation in E. to.; firmness of an irritant in relation to phagocytes; high local concentration of these irritants. Stimulators of transformation of mononuclear phagocytes in E. to. pathogenic microorganisms, nucleotides, anion molecules, antibodies against membranes of macrophages, the digested particles or substances and especially lymphokines are. Bibliography: The general pathology of the person,

under the editorship of A. I. Strukov, etc., M., 1982; Serov V. V. and V. S Spiders. Ultrastructural pathology, M., 1975; Chernukh A. M. Inflammation, M., 1979; Adams D. Lake of The granulomatous inflammatory response, Amer. J. Path., v. 84, p. 164, 1976; Warren K. S. Granulomatous inflammations, in book: Inflammation, Mechanisms and control, ed.

by I. H. Lepow a. P. A. Ward, p. 203, N.Y. — L., 1972. V. V. Serov.