From Big Medical Encyclopedia

UIPPL George (Whipple George Hoyt, 1878 — 1976) is the American pathologist, the academician of National academy of Sciences of the USA, the Nobel Prize laureate (1934).

In 1900 ended Yale un-t, in 1905 — medical school Un-ta of J. Hopkins, till 1914 worked at department of pathology of it un-that. In 1914 — 1921 the director Hou of perovsky fund of researches in the field of medicine and professor of medical school Californian un-that in San Francisco. Since 1921 professor of pathology (till 1955) and the dean (till 1953) schools of medicine and stomatology in Rochester.

J. Whipple published 270 scientific works on problems of a patomorfologiya and experimental pathology. In 1907 it described the disease similar about a wedge, a picture to a spr which is characterized by adjournment of lipids in limf, nodes and a mucous membrane of a small bowel nowadays known under the name «Whipple's disease» (see. Intestinal lipodystrophy). Other its researches in the early period of its activity are devoted patol. anatomy of tuberculosis and a number of tropical diseases, an origin and function of bilious pigments it is normal also at pathology. The research of a role of various foodstuff in regeneration of hemoglobin became the most important direction of its subsequent works. In 1923 he developed in an experiment on dogs model of the anemia caused by repeated bloodlettings and established that the special diet, the main component a cut is a liver, provides regeneration of hemoglobin. Based on these works, J. Minot and U. Murphy (1926) offered a method of treatment by a crude liver of patients with pernicious anemia.

For development of an effective method of treatment and prevention of pernicious anemia J. Whipple together with J. Minot and At. Murphy is conferred the Nobel Prize on physiology and medicine.

Works: A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues, Bull. Johns Hopk. Hosp., v. 18, p. 382, 1907; Hemoglobin regeneration as influenced by diet and other factors, Nobel Prize lecture, J. Amer. med. Ass., y. 104, p. 791, 1935; Mediterranean disease, thalassemia (erythroblastic anemia of coo-ley), associated pigment abnormalities simulating hemochromatosis, J. Pediat., v. 9, p. 279, 1936.

Bibliography: Beyer V. A. To 100

anniversary since the birth of Whipple, Klin., medical, t. 57, No. 3, page 117, 1979;

Cor ner G. W. George Hoyt Whipple and his friends, life-story of a Nobel Prize pathologist, Philadelphia, 1963.

JI. I. Aruin.