TYRAMINE — β-(n-oxyphenyl) - ethylamine, arylamine of a fatty series; physiologically active agent, possesses angiotonic action, influences processes of excitement and braking in a nervous system, is toxic.
T. it is found in an ergot, aged cheese, food raw materials, and also in products rotting (see) an organic residues. Pier. the weight (weight) of tyramine 137,18, t°pl 164 — 164,5 °, t°kip 175 — 178 °, it we will badly dissolve in water, it is sparingly soluble in hot xylol (see).
T. it is formed as a result decarboxylations (see) amino acids tyrosine (see) with the participation of specific decarboxylases (see). In a human body and animal T. is generally waste product of putrefactive intestinal microflora and it is formed at a fate and microbic decarboxylases; decarboxylation of tyrosine in tissues of the person and animals usually happens slowly and is not of great importance in metabolism of this amino acid. T., soaking up in blood, it is effectively neutralized monoamine oxidase (see). At the patients accepting monoamine oxidase inhibitors as pharmaceuticals (see. Psychopharmacological means ), hypertensive crisis can develop (see. Crises ) under the influence of T., soaked up from intestines; cases of death of patients in such situation are known.
Bibliography: Gorkin V. 3. Aminoxidases and their value in medicine, M., 1981; M e c D. Biokhimiya's ler, the lane with English, t. 3, page 344, M., 1980.
H. N. Chernov.