TROPHEDEMA

From Big Medical Encyclopedia

TROPHEDEMA (trophoedema; Greek trophe food, food + oidema tumor, hypostasis; synonym: lymphatic hypostasis, a disease of Meyzha, a disease of Mylae of a swarm, a disease to Nonna, a syndrome to Nonna — Milroy — Meyzha, a chronic hereditary trophedema) — the hereditary disease which is shown chronic hypostasis of soft tissues of the lower extremities.

For the first time hron. hypostasis on the lower extremities was described by R. Virkhov in 1863 under the name «lymphatic hypostasis with malformations». Then this pathology was described by M. to Nonna (1891), Milroy (W. F. Milroy, 1892) and Meyzh (H. Meige, 1899), to-ry offered the term «trophedema». Meyzh defined T. as the damage of the lower extremities which is characterized hron. white firm painless hypostasis, one - or bilateral, meeting in the form of sporadic cases or as family and hereditary, sometimes an inborn disease.

The etiology is not found out. There is an opinion that genetically caused insufficiency diencephalic gshyufizar is the cornerstone - ache systems what hereditary and family character of T testifies to., inherited on an autosomal domi-nantnomu to type. In development of pathological process environmental factors have a certain value (an infection, an injury, intoxication, etc.).

According to Kvak (J. M of Quack, 1969), in the area hron. hypostasis observe sharp to the umenypeena of quantity (up to total disappearance) hypodermic cellulose, fibrosis, and also a hyalinosis of hypodermic fabrics, a loosening of muscle fibers.

T. meets at women usually against the background of infantility, the small growth, a hypogenitalism, a delay of mental development more often (sometimes to full weak-mindedness).

Hypostasis develops on shins, more often happens symmetric, painless, can sometimes extend to a hip, but never rises above an inguinal fold. In extremely exceptional cases hypostasis can arise on hands. Skin in the field of hypostasis has pale coloring, its temperature always normal.

At survey note valgus deformation of a shin and foot, a kyphosis of chest department of a backbone. At a biochemical blood analysis the hypoproteinemia is observed. Calais contains a large amount of protein.

T. has bent to hron. to a current. During puberty progressing of process is noted.

T. differentiate with hron. the hypostases which are localized in different areas of a body: on a face, a trunk, upper extremities. These hypostases earlier mistakenly carried to T. Hron. hypostases on a face are a symptom of various diseases what features their wedge, manifestations testify to. They can proceed in the form of a granulematozny heylpt — at Misher's syndrome (see the Cheilitis), a granulematozny glossitis — at Melkersson's syndrome — Rosenthal (see Melkersson — Rosenthal a syndrome), a craw — at Asher's syndrome (see Asher a syndrome). Hron. hypostases in other parts of a body should be regarded as various nozol. forms depending on features a wedge, manifestations. Possibly, the scleroderma in most cases takes place (see).

Besides, T. it is necessary to distinguish from elephantiasis (see), and also hypostases at Shereshevsky's syndrome — Turner (see Turner a syndrome), Laurence's syndrome — Muna — B and for (see Laurence — Muna — B of ides of la a syndrome), etc. Question of communication hron. the hypostases arising on a face and in other areas of a body with T. demands further researches.

Symptomatic treatment. In some cases to improvement of the general state leads use of antihistaminic drugs, corticosteroids, gamma-globulin, vitamins to reduction of hypostasis and nek-rum.

The forecast for life favorable.

Bibliography: R at and in L. R. Trofodem Meyzha, Owls. medical, JMe 11, page 78, 1956; it e, Swelled Meyzha and his options, Klin, medical, t. 43, No. 9, page 126, 1965; Chebotaryov K. Page and X e y e t I am N of X. X. Case of trophic hypostasis of Milroy — Meyzha, Vestn. dermas, and veins., LG? 8, page 49, 1979; M e i g e H. Le trophoedeme chro-nique hereditaire, N. Iconogr. Salpet., t. 12, p. 453, 1899; about N of e. Sur] e trophoedeme, ibid., t. 14, p. 465, 1901.

Century of E. Grechko.

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