From Big Medical Encyclopedia

TROMBOGEMORRAGYCHESKY SYNDROME (TGS; the Greek thrombo [des] condensed - f haimorrhagia bleeding; a syndrome) — the symptom complex accompanying pathology and extreme influences, caused universal and the не-специфическпм is reversible and irreversible to be condensed by property of blood, a lymph, intercellular lymph, cellular and intercellular structures owing to activation of their coagulability and as a result of retraction to be stratified on components of various aggregate state.

Enters a pathogeny of a number of diseases. The syndrome is for the first time described in 1962 by M. S. Machabeli.

The condensation and stratification begins in cells of fabrics of sick body and turns into reaction of «release» from them so-called koagulyatsi-onno-lytic substances, to-rye activate an interintercellular lymph, angienchymas, a lymph, blood (the 1st stage of TGS), and cause the incomplete disseminated intravascular coagulation (transition to

the 2nd stage of TGS) or the full disseminated intravascular coagulation (transition to the 3rd stage of TGS). An intravascular blood coagulation breaks food of fabrics of healthy bodies, causes a hypoxia, disbolism and «on coercion» involves them in patol. process (4th stage of TGS).

Divides extravasated links of a trombogemorragichesky syndrome of M. S. Machabeli into three look: 1) cellular extravasated coagulation,

2) generalized extravasated coagulation, 3) the localized extravasated coagulation.

Knowledge clinical physicians of the provisions described above, i.e. the fact that behind the hemorrhagic phenomena (from pe-silent to profuse bleedings) disappear trombotichesky (from intracellular condensations in fabrics to intravascular thromboses) allows them, in addition to specific etiotropic treatment, to appoint correct nonspecific pathogenetic (heparin and other universal regulators of fabric exchange). The held events promote a stop of trombogemorragichesky reactions (transition to a recovery stage) and thus stop patol. process.

See also Trombogemorragichesky syndrome, t. 29, additional materials.