TRIOXAZINUM

From Big Medical Encyclopedia

TRIOKSAZYN (Trioxazin; synonym: Sedoxazin, Trimetozinum, etc.; SI. B) — tranquilizing means. N (3, 4,5-Trimetoksibenzoit) - tetrahydro-1,4-oxazine; C14H19N 05:


White crystal powder, slightly soluble in water.

In an experiment of T. has the calming effect, breaks approximately - research reflexes, reduces a physical activity, oppresses conditioned defensive reflexes, normalizes behavior in a conflict


tion of a situ, exponentiates action of hypnagogues and anesthetics, causes a hypothermia. On activity concedes to tranquilizers of a benzodiazepine row — to diazepam (see), to Phenazepamum — and contrary to them has almost no protpvosudorozhny properties, does not oppress polisinaptichesky reflexes and does not render the muscular weakening action. T. stimulates consumption with a brain of oxygen, increases the maintenance of ADF.

On a wedge, to observations weakens alarm, tension and sensation of fear, reduces motive concern. At introduction inside it is quickly soaked up from went. - kish. path. The hl is allocated. obr. with urine.

Apply T. at neurotic and neurosis-like states, if necessary combine with other tranquilizers (see) or neuroleptics (see Neuroleptics). Due to the lack at T. the muscular weakening effect it is reasonable to apply it on an outpatient basis as a tranquilizer of day action.

Appoint inside the adult 0,3 g (1 tablet) 2 — 3 times a day. The maximum daily dose shall not exceed 3 g. To children the dose is reduced according to age, appointing on V4 — 1/2 tablets to reception of 3 — 5 times a day.

Side effects (slackness, weakness, drowsiness, allergic reactions) can arise generally at use of drug in high doses.

Form of release: tablets on 0,3 g. Store in the dry, cool place.

T. A. Voronina.

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