From Big Medical Encyclopedia

TRYoYDELENBURG Paul (Trendelenburg Paul, 1884 — 1931) — the German pharmacologist, the son F. Tren, - a delenburga.

Studied medicine in Grenoble, Leipzig and Freyburge where in 1909 ended medical f-t and worked as the assistant V. Shtrauba at department of pharmacology. Since

1916 professor, since 1918 the department chair of pharmacology in Tear up (Tartu). From 1919 to 1923 the department chair of pharmacology in Rostock.

From 1923 to 1927 professor un-that in Freyburge, and since 1927 — in Berlin.

P. Trendelenburg is an author more than 120 scientific works devoted to studying of influence pharmacological of active agents on cardiovascular and digestive systems, hemadens, etc. He established the first pharmacological activity of glycosides of a foxglove (1909), applied to experimental pharmakol. researches serdschno-pulmonary drug. Together with

S. V. Anichkov opened ability of glycosides of a foxglove to have the expressed kardpotoipche-sky effect and to increase a coronary blood stream at experimental heart failure (1928). P. Trendelenburg paid much attention to development of the methods allowing to study effect of biologically active agents on an organism in general and on bodies with the kept innervation and food. The techniques of registration of the peristaltic movements of the isolated gut of a rabbit offered them, and also registration of a vermicular movement of shtgaktny intestines (1913) allowed to conduct basic researches of motive function of intestines (1917). P. Trendelenburg found adrenaline in blood and studied influence of various factors on release of adrenaline from marrow of adrenal glands (1915). He carried out comparative study of influence on blood circulation of analeptpk, adrenaline, ephedrine, a spmpatol and nek-ry other simpa-tompmetik. The technique of perfusion of the isolated extremities of a frog is called by the name of the Item Trendelen-burga.

It conducted also a number of researches on studying of hormones of a hypophysis and parashchntovidny glands, a re'zulta you to-rykh Hormones were generalized in the two-volume monograph «. Their physiology and pharmacology» (1929, 1934).

Works: Physiologische und pharmakologische Versuche iiber die Diinnaarmpei istaltik, Arch. exp. Path. Pharmak., Bd 81, S. 55, 1917; Die Adrenalmsecretion unter norma-len und gestorten Bedingungen, Ergebn. Physiol., Bd 21, S. 500, 1923,

Quartiire Ammonium-Verbindungen und Korper mit verwandter Wirkung, Handb. exp. Pharma-kol., hrsg. v. A. Ilefier, Bd 1, S. 564, B., 1923; Adrenalin und adrenalinverwandte Substanzen, ibid., Bd 2, Hft 2, S.

1130, B., 1924; Pharma kologie und Physiologic des Hypophysenhtnterlappens, Ergebn. Physiol.,* Bd 25, S. 364, 1926; Grundlagen der allgemeinen und speziellen Arzneiveror-dnung, Lpz., 1926, B., 1938 (Russian lane, Kharkiv, 1928); Die Wirkung des Strophanthine auf’das suffiziente und auf das insuffi-ziente Warmbluterherz, Dtsch. med. Wschr., S. 1672, 1928 (sovm. with Anitschkow S. V.); Die Hormone, Ihre Phvsiologie und Phar-makologie, Bd 1 — 2, B., 1929 — 1934 (pyc. the lane, M. — L., 1932 — 1936).

Bibliography: JanssenS. u. P i e t r-k o w s k i G. Paul Trendelenburg, Miinch. med. Wschr., S. 452, 193 1; Readings in pharmacology, ed. by B. Holmstedt a.

G. Liljestrand, Oxford a. o., 1963; S t r o-o m a n n G. Paul Trendelenburg, Ergebn * Physiol., Bd 32, S. V, 1931. V. G. Dagurov.