From Big Medical Encyclopedia

THIOUREA (thiocarbamide, diamide of thiocarbonic acid) — sulphurous analog of urea; has biological activity.

In medicine derivative T., thanks to their cytostatic properties, use as the anti-thyroid means (see) reducing function of a thyroid gland (see). T. specifically inhibits urease (see). Concerning plants of T. shows toxicity, it is used also as fungicide. T. finds broad application in organic synthesis, including for receiving pharmaceuticals (see).

T. represents colourless crystal substance of bitter taste, t°pl 180 — 182 ° (at bystry heating), well the rastvorima in water, alcohol, pyridine, is difficult ether-soluble. Receive T. thermal isomerization of ammonium thiocyanate or accession hydrogen sulfide (see) to cyanamide. On chemical properties T. reminds urea (see), reactions on sulfur atom are most characteristic of it (see). With strong to-tami and the bases of T. forms salts, alkylation of T. leads to formation of the alkilizotiouroniyevy salts used for receiving mercaptans (see). With salts of metals T. gives complex connections (see), and at oxidation depending on conditions — a disulfide or formamidinesulphinic to - that, applied in biochemical and biol. researches.

Bibliography: Nenitsesku K. D. Organic chemistry, the lane from Romanians., t. 1, page 822, M., 1962.

N. F. Tolkachevskaya.