THIOPHOSPHAMIDUM (Thiophosphamidum; synonym: TIOTEF, Tespamin, TESPA, STEPA, Tifosyl, Tiofosyl, TSPA, TioTEPA, Thiotepum, Qirostan, NSC-6396; joint venture. A) — antineoplastic cytostatic means alkylating like action. Rub (ethylene) triamide of thiophosphoric acid; With 6 H 12 N 3 PS:
White crystal powder, well water soluble, alcohol, chloroform, benzene, ether. It is non-hygroscopic, t°pl 52 — 54 °. Water solutions are unstable and do not give in to thermal sterilization since are easily hydrolyzed.
T. has antimitotic activity and suppresses function of proliferating fabrics (marrow, a spleen, a mucous membrane of intestines, etc.). In animal experiments slows down growth of the intertwined tumors. DL 50 for rats at single intravenous administration makes 8,4 mg/kg. Drug has cumulative properties.
T. apply at cancer ovaries (see), cancer of petty gland (see), mesothelioma of a peritoneum (see. Mesothelioma ). Enter it intramusculary, intravenously, in belly and pleural cavities, directly into a tumor on 5 — 10 mg daily or every other day (at hemoblastoses) or on 10 — 20 mg in 2 — 7 days (at tumors). The course dose averages 100 — 200 mg. If necessary the course of treatment can be repeated. Treatment is carried out under a careful gematol. control. At overdose or hypersensitivity to drug development of a leukopenia (see) and thrombocytopenia is possible (see). In these cases use of drug is immediately stopped and carry out the haemo stimulating therapy.
It is contraindicated at the general serious condition of the patient and the cachexia expressed to a leukopenia, thrombocytopenia and anemia active that is, a berkuleza, disturbance of functions of a liver and kidneys, heavy cardiovascular insufficiency.
Form of release: hermetically the corked bottles on 0,01 or 0,02 g in the form of powder or tablets. Store in the dry cool place.
See also Antineoplastic means .
Bibliography: Bulkina 3. P. Antineoplastic drugs, page 105, Kiev, 1978; Perevodchikova N. I. Clinical chemotherapy of tumoral diseases, M., 1976.
V. A. Chernov.