THIOPENTALUM-NATRIUM (Thiopentalum-natrium; joint venture. B) — means for not inhalation anesthesia. Mix 5-etil-5-(2 amyl) - 2 thiobarbiturates of sodium with anhydrous sodium carbonate; With 11 H 17 O 2 N 2 SNa + Na 2 CO 3 :
Similar drugs release abroad under names: Pentothal sodium, Thiopental sodium, Thiopentobarbital, Thiopentone sodium, etc.
The dry porous mass of yellowish or yellowish-greenish color with a peculiar smell. It is hygroscopic, we will easily dissolve in water, it is almost insoluble in benzene and ether. Water solutions have alkali reaction. Solutions T. - N are unstable therefore they are trained in aseptic conditions just before the use.
At intravenous administration of T. - N. anesthesia (see) comes in 30 — 40 sec. without stage of excitement. Duration of an anesthesia is 15 — 25 min. Short duration of effect of T. - by N it is connected with redistribution of drug in an organism, in particular with its accumulation in large numbers in fatty tissue. In a liver of T. - the N is slowly inactivated.
It is similar to others to barbiturates (see). T. - the N has weak anal-Gothic properties. In nek-ry cases at use in an inadequate dosage can increase sensitivity to pain.
T. - the N causes respiratory depression. Degree of respiratory depression is proportional to a dose of drug. At slow introduction of T. - the N in average narcotic doses is observed passing decrease in the ABP. During an anesthesia there can sometimes be arrhythmias connected with a hypercapnia. Cordial emission usually goes down a little, the general peripheric resistance does not change or increases. The blood stream in skin and a brain decreases, in other bodies significantly does not change. However at the hypovolemia connected with blood loss and also at the shock, sepsis and nek-ry other states which are characterized by circulator disturbances, moderate doses of T. - N can cause a collapse (see). T. - the N does not change concentration of catecholamines in plasma, does not increase sensitivity of a myocardium to adrenaline. It reduces the speed of metabolic processes in tissue of a brain, and also lowers intracranial pressure. Relaxation of skeletal muscles under the influence of T. - to N it is expressed slightly. T. - the N influences sokratitelny activity of a myometrium a little. It gets through a placental barrier and can exert the oppressing impact on a fruit. Functions of a liver and kidneys decrease only at use of T. - N in high doses.
Use T. - N generally for an introduction anesthesia. Solutions of thiopental-sodium apply 1 — 2% to these purposes, to-rye prepare on physiological solution.
At first enter into a vein 1 — 3 ml of solution, and in 30 — 40 sec. other quantity. A pause in the course of introduction of T. - for N it is necessary to reveal existence of hypersensitivity to drug. The introduction anesthesia on average requires 0,2 — 0,4 g of thiopental-sodium.
The highest one-time and daily doses for intravenous administration in adult 1 g.
T. - the N can cause cough (see), laryngospasm (see), bronchospasm (see), to-rye usually disappear during the deepening of an anesthesia. At hypodermic introduction of T. - the N in connection with alkaline property of its solutions renders the expressed irritant action up to a necrosis. At hit of solution T. - the N in an artery arises a resistant spasm that can lead to gangrene of fabrics (see. Gangrene ).
T. - the N is contraindicated at shock, a decompensation of cordial activity, the expressed hypotension and a hypovolemia, diseases causing disturbance of passability of upper respiratory tracts, bronchial asthma, organic diseases of a liver and kidneys, a diabetes mellitus, an addisonovy disease, the expressed acidosis, severe exhaustion, feverish states. Use of T is undesirable. - N in obstetric and pediatric practice, at a myasthenia.
During the mixing of solutions T. - the N with Dithylinum, tsentaminy, arfonady, isopromethazine or aminazine has a deposit.
Form of release: on 0,5 and 1 g in glass bottles, bottletight rubber bungs, pressed out by aluminum caps. Store in the cool dry place protected from light.
See also Not inhalation anesthesia .
Bibliography: The reference book on anesthesiology and resuscitation, under the editorship of A. D. Bu ~ N yatya on, page 6, 149, M., 1982; The pharmacological basis of therapeutics, ed. by A. G. Gilman a. o.t N. Y., 1980.
V. V. Churyukanov.