From Big Medical Encyclopedia

THE VENTRICLE ISOLATED (synonym: the ventricle is small, a ventricle lonely) — the ventricle formed in the surgical way from a part of a stomach of an experimental animal in the experimental purposes. and. effects of medicinal substances etc. are used for studying of function of a stomach, a feeding behavior of animals.

For the first time. and. it was formed by Klemensevich (R. Klemensiewicz, 1875) of a peloric part of a stomach. R. Geydengayn (1879) offered modification. and. from a fundal part for studying of patterns of secretion of fundamental glands of a stomach.

According to R. Geydengayn. and. it is found from a greater cul-de-sac and completely cut from its other part. At the same time the nerves going to gastric glands are cut, and communication with all organism remains only through circulatory system. In 15 — 30 min. after feeding of an animal from. and., on Geydengayna, it was allocated gastric juice (see).

Fig. The flow diagram of creation of the isolated ventricle according to Pavlov: and — a stomach of a dog before operation (1 — the line of a section, 2 — branches of a vagus nerve); — operation is complete, the arrow specified the created isolated ventricle. The front wall of a stomach is partially removed for descriptive reasons.

I. P. Pavlov, aiming to keep an innervation of gastric glands, developed a technique, at a cut the branches of a vagus nerve going to glands of fundal were not cut. and. Feature of this operation is that at cutting out. and. in that part of big curvature where from a gullet fibers of a vagus nerve go down, make a section not of all layers of a wall of a stomach but only mucous and submucosal covers. Serous and muscular covers, between to-rymi go down branches of a vagus nerve, remain untouched. The mucous membrane together with submucosal is otslaivat in the area of a section in both parties and sewn up in the form of a tobacco pouch (fig). After that on all line of a section put stitches on a serous and muscular layer. Thus, thanks to the remained bridge connecting serous muscularly between a stomach and. and. fibers of a vagus nerve remain and the normal innervation is provided. and.

Secretion of the Pavlovsk ventricle begins in 6 — 8 min. after feeding and more plentifully, than secretion. and. on Geydengayna.

Ivy and Farrell (A. S. Ivy and J. I. Farrell, 1925) made operation of change of completely isolated fundal ventricle to the area of chest gland of a dog. Such completely denervated and eating at the expense of vessels of skin. and. in connection with meal cosecreted, however not at once, and only 3 — 4 hours later after feeding. Existence of humoral influences was so finally proved, thanking the Crimea there is a secretion of gastric glands. In laboratory K. M. Bykova operations on creation of the isolated Pavlovsk stomachs from big and small curvature of a ventricle were made. Secretion of the ventricle formed of small curvature began earlier and was bigger in comparison with secretion. and., formed of big curvature.

Was of great importance for studying of gastric secretion. and., formed of a peloric part of a stomach. As at the same time resect all peloric part of body, for passing of food impose gastroenterostomoz. The peloric part which is cut off from a stomach on the tour end tightly is sewn up, and on the duodenal end the free opening is brought to skin of an abdominal wall. Century V. Savich (1921) developed a technique of creation peloric. and. with preservation of an innervation, like operation of the Pavlovsk fundal ventricle. Further the technique of full denervation of a peloric ventricle by its removal in a skin rag was developed. The irritation of a mucous membrane of such ventricle caused secretion of fundal glands of a stomach that finally proved the humoral mechanism of information transfer from a peloric part on fundal glands of a stomach in hron, an experiment.

Bibliography: Asmayan N. V. A role of a peloric part of a stomach in secretion of fundal glands, Bulletin Ekspery, biol, and medical, t. 35, No. 3, page 11, 1953; Pavlov I. P. Complete works, t. 2, book 2, M. — L., 1951; Human physiology, under the editorship of E. B. Babsky, page 178, M., 1972.

N. V. Asmayan.