THEMISAL (Themisalum; synonym: Diuretinum, Diuretinum, Theobrominum natricum et Natrii salicylas, Theobrosal etc.; GFH) — vasodilating and diuretic. Theobromine-sodium with sodium salicylate; With 7 H 7 N 4 NaO 2 + With 7 H 5 NaO 3 :
White powder. On air absorbs carbonic acid. It is hygroscopic. Water solution has alkali reaction. Let's very easily dissolve in water, it is almost insoluble in ether and chloroform; pier. weight (weight) theobromine-sodium 202, 15, sodium salicylate 160,11. Water solutions are incompatible with carbonic salts and to-tami.
On pharmacological properties corresponds to theobromine (see) also has poorly expressed diuretic and vasodilating effect. On c. the N of page exerts very weak stimulating impact. On the mechanism of action corresponds to theobromine and other alkaloids of a purine row. Vasodilating action of T. it is most expressed concerning vessels of heart and kidneys.
Apply at hypostases of a cordial and renal origin, at laid down-gikh forms of an idiopathic hypertensia and hron. coronary insufficiency usually in a combination with other vasodilators. Now according to these indications of T. use rather seldom since by efficiency it considerably concedes to the modern drugs which are used at the same time.
Appoint inside the adult on 0,3 — 0,5 — 0,75 g, children till 1 year — on 0,03 — 0,05 g, 2 years — 0,15 g, 3 — 4 years — 0,2 g, 5 — 6 years — 0,25 g, 7 — 9 years — 0,3 g, 10 — 14 years — 0,3 — 0,5 g on reception 3 — 4 times a day.
Form of release: powder. Store in well corked container protecting from effect of light and moisture. During the moistening breaks up to theobromine-sodium and sodium salicylate.
V. K. Muratov.