TERPIN HYDRATE (Terpinum hydratum; GFH) — an expectorant. N-Mentandiol-1,8 hydrate; With 10 N 20 About 2 - H 2 O:
Receive by hydration of the gum spirit of turpentine purified (see. Turpentine ).
Colourless transparent crystals or inodorous white crystal powder, poorly bitter taste. At careful heating to t ° 100 ° it is sublimated, forming acicular crystals. We will dissolve in a cold water a little (1: 250), chloroform, ether and turpentine. Let's difficult dissolve in a boiling water (1: 34), we will dissolve in 95% alcohol, we will easily dissolve in the alcohol boiling 95%; t°pl 115 — 117 °; pier. weight (weight) 190,28.
T. treats expectorants of direct type of action. Strengthens secretion of bronchial glands and causes fluidifying of a phlegm. At intake it is easily soaked up from went. - kish. a path and in not changed look partially it is allocated with bronchial glands, causing at the same time irritation of ferruterous fabric that is followed by strengthening of their secretory activity. T. apply as an expectorant at nek-ry diseases of lungs, napr, at hron. bronchitis, pneumonia, bronchoectatic disease, etc.
Appoint inside the adult on 0,25 — 0,5 g on reception 3 times a day; to children till 1 year on 0,025 — 0,05 g, up to 2 years 0,05 g, from 3 to 4 years 0,1 g, from 5 to 6 years 0,15 g, from 7 to 9 years 0,2 g, from 10 to 14 years 0,25 — 0,3 g on reception 2 — 3 times a day.
Drug is well transferred. In high doses (St. 1,5 g a day) reduction of secretion of bronchial glands can cause.
Forms of release: powder, tablets on 0,25 and 0,5 g Besides, are produced the tablets containing 0,25 g of terpin hydrate and Natrii hydrocarbonas. Store in well corked container.
See also Expectorants .
Bibliography: Clinical pharmacology, under the editorship of V. V. Zakusov, page 305, M., 1978.
V. K. Muratov.