TEMECHINUM (Temechinum) — ganglioblokiruyushchy means. 2,2,6,6-Tetrametilkhinuklidina hydrobromide; With 11 H 21 N-HBr:
Crystal powder, white or white with subtle creamy shade. Let's very easily dissolve in water, it is easy — in alcohol; pH of 1% of solution 5,6 — 7,0. On pharmakol. to properties and structure it is similar with Pyrilenum (see) is also its hinuklidinovy analog.
Oppresses transfer of excitement in vegetative gangliya, blocks N-holinoretseptory of a sinocarotid zone and marrow of adrenal glands, breaks synoptic transfer of excitement in cholinergic synapses of c. N of page. Does not affect N-holinoretseptory of skeletal muscles.
Apply T. at an idiopathic hypertensia, spasms of peripheral vessels, an obliterating endarteritis, a peptic ulcer of a stomach and duodenum. It is effective at hypertensia of a small circle of blood circulation.
Appoint inside after food the adult on 0,001 — 0,002 g 3 — 4 times a day or subcutaneously in the form of 0,1% of solution on 0,5 — 1 ml of 1 — 2 — 3 time a day. Course of treatment from 4 to 8 weeks. For stopping of hypertensive crises of T. enter intramusculary on 0,75 — 1 ml 0,1% of solution.
T., as well as other ganglioblokator, can cause side effects (locks, tachycardia, dryness in a mouth, etc.).
It is contraindicated at the expressed atherosclerosis, organic lesions of a myocardium and parenchymatous bodies, at glaucoma and an atony of intestines.
Form of release: tablets on 0,001 g and ampoules on 1 ml of 0,1% of solution. Store in the place protected from light.
See also Ganglioblokiruyushchy means .
Bibliography: Zozulya I. S., Panikarsky V. G. of R. I ideushev. Use of Haemitonum and Temechinum at an idiopathic hypertensia, the Doctor, business, No. 4, page 85, 1976; Nogaller A. M. and Khan V. G. Treatment of patients with a peptic ulcer with Temechinum, Klin, medical, t. 53, No. 10, page 52, 1975; Sharapov I. M. To pharmacology of Temechinum — new Ganges-lioblokiruyushchego of drug, Pharm. and toksikol., t. 35, No. 6, page 687, 1972.
D. N. Samoylov.