From Big Medical Encyclopedia

SYNERGISM (Greek synergia assistance, cooperation) — the interaction of various biochemical and physiological processes, separate elements (parts) of the whole organism directed to achievement of final adaptive effect optimum at present.

In S.'s biochemistry it is expressed in interaction of various metabolic processes, a cut changes kinetics of biochemical reactions or the number of the connections which are formed at the same time.

Reflects the nature of the interaction of various microorganisms in a vegetable or animal organism directed to strengthening of a certain culture of microorganisms or its immunizing influence in S.'s microbiology.

In S.'s physiology it is shown both at the level of groups of muscles, and at the behavioural level. In particular, the final adaptive effect of muscle work, having various properties (e.g., intercostal, interchondral muscles, a diaphragm), consists in providing normal external breath (see) due to space and temporary synchronization of their activity. The page provides operational, flexible adaptation of an organism to influence of external conditions. Mechanisms of maintenance of vertical poses (see) create a possibility of simultaneous inclusion of various groups of muscles of the lower extremities and a trunk depending on those conditions, in to-rykh the pose is supported. On the basis of S. the coordinated recovery of functions of the main fiziol is carried out. life support systems (e.g., breath and blood circulation). The page in physiology, thus, is one of manifestations self-control of physiological functions (see).

In S.'s pharmacology designates the unidirectional nature of effect of several chemical substances assuming achievement of higher final effect than at action of each of them separately (see. Synergism of medicinal substances ). At the same time, if influence of drugs represents the sum of effects of action of everyone, such action call summing up pl the additive (e.g., use of chloroform and ether, the c having the identical mechanism of impact on cells. N of page). If at the consecutive or combined use of several substances the final effect is more than the sum of effects of each of substances, then speak about potentiation.

Bibliography: Anokhin P. K. Biology and neurophysiology of a conditioned reflex, M., 1968; it, Nodal questions of the theory of functional system, M., 1980; Gurf and N to e l V. S. and d river. The organization of interarticular interaction on the example of compensation of respiratory indignations of an orthograde pose of the person, in book: Models of the structurally functional organization of some biol. systems, under the editorship of I. M. Gelfand, etc., page 310, M., 1966; M at r and in e in I. A., To z ý-m and V. D.'s N and To at d r and ii A. N. Nesovmestimost of medicinal substances, M., 1978; V i and of s P. et Seebacher J. Les interferences medicamen tenses, risques therapeutiques et incompatibilites, p. 120, 253, P., 1973.

G. Ts. Agayan.