From Big Medical Encyclopedia

SULZBERGER — GARBE THE DISEASE (M of V. of Sulzberger, amer. doctor; W. Garbe, sort. in 1908, the Canadian dermatologist; synonym chronic exudative diskoidny and lichenoid dermatosis) — the dermatosis which is characterized by emergence of plazmotsitarny infiltrates around expanded vessels of skin and shown development of the shelled, usually pruritic plaques.

Page — G. it is described by Sulzberger and Garbe in 1937. The etiology of a disease is unknown; nek-ry researchers consider it as a rare form neurodermatitis (see).

Patogistologiya: in epidermis it is noted spongiosas (see) or insignificant hypostasis and acanthosis (see); nipples are extended; in an upper part of a derma — perivascular infiltrates from lymphocytes, histiocytes, polymorphonuclear neutrophils, eosinophils and a large number of plasmocytes.

The disease arises more often at men of 40 — 50 years and is characterized by variety of the replaced skin manifestations. Originally they have looking alike dermatitis (see. Dermatitis ), eczema (see) or dyshydrosis (see). Process consistently accepts the disseminated character, the centers of defeat get sharp borders, an oval or disk-shaped form; periodically through various time terms (several days or weeks) there is exudation (the smallest vesicles and superficial to a moknutya). After its subsiding a part of the centers is allowed, but the majority infiltrirutsya and lichenified, gaining looking alike limited neurodermatitis. Also scattered small knots of sinyushnokrasny color externally similar to rashes at red flat herpes are characteristic (see. Deprive red flat ). Approximately a half of patients has blisters, more resistant, than at an ordinary small tortoiseshell. At height of a course of a disease the centers of defeat are localized on a trunk (along edges), hips, but can be on any site of skin. At men genitalias, especially a balanus, as a rule, are surprised. Patients are disturbed by a sharp itch, as a rule, at night. Seborrheal baldness can be observed (see. Alopecia ), moderate adenopathy. In blood the eosinophilia (from 5 to 60%) often comes to light. Disease long with aggravations and remissions.

Diagnosis is based on a wedge, features of damage of skin and patogistologichesky data.

Treatment: the temporary effect is rendered by the corticosteroid hormones applied inside or outwardly in the form of ointments, and also ointment with the antipruritic and allowing means (menthol, Dimedrol, tar).

Forecast for life favorable.

Bibliography: Raznatovsky I. M. and Rodionova. H. A chronic exudative diskoidny and lichenoid dermatosis of Sulzberger — Garbe, Vestn. dermas, and veins., No. 1, page 68, 1976; Sulzberger M. B. a. Garb e W. Nine cases of a distinctive exudative discoid and lichenoid chronic dermatosis, Arch. Derm. Syph. (Chic.), v. 36, p. 247, 1937; Sulzberger M. B., March C. a. G and at C. Besondere exudative discoide und lichenoide chronische Dermatose, Z. Haut-u. Geschl. - Kr., Bd 27, S. 223, 1959.

O. K. Shaposhnikov.