SULFATIDES

From Big Medical Encyclopedia

SULFATIDES (synonym sulfolipids) — the difficult lipids containing sulfonate group; represent sulfates of cerebrosides (cerebroside-sulfates). Genetically caused disturbance of exchange of S. is the reason of heavy hereditary enzymopathies, including such as a metachromatic leukodystrophy (a sulfatidny lipidosis) and sulfatidoz juvenile (see. Glikozidoza ; Lipidoses ). The pages including sulfosphingolipids, sulfoglycerogalactolipids and steroidsulfolipida participate in creation of cellular and subcellular membranes, in particular a myelin (see. Nervous system ).

Pages in a human body and animals are formed as a result of etherification sulfuric to - that 3' - OH - groups of the rest of a galactose in a molecule cerebrosides (see). At hydrolysis the molecule C. breaks up to a galactose, fat to - that, amino alcohol sphingosine (see. Sphingosines ) and sulfuric to - that. Separate S. differ with the nature of the rest fat to - you, acylating an amino group of sphingosine.

Pages are found in all bodies and tissues of animals and the person, their content in tissue of a brain where they make up to 25% of all cerebrosides is especially high. In the same fabric there is a specific sulphatase (see Suljfataza) splitting S. to inorganic sulfate and galaktozil-ceramide. The page of a bit different nature (contain glycerin, the rest olein to - you and sulfonic acid of a galactose) are allocated from microorganisms and the higher plants.

See also Lipids .



Bibliography: Metsler D. Biochemistry, Chemical changes in living cell, the lane with English, t. 1, page 341, M., 1980; F and-rooqui A. A. Metabolism of sulfolipids in mammalian tissues, Advanc. Lipid Res., v. 18, p. 159, 1981; Goldberg I. H. The sulfolipids, J. Lipid Res., v. 2, p. 103, 1961.


H. G. Budkovskaya.

Яндекс.Метрика