SULFAPYRIDAZINUM (Sulfapyridazinum; synonym: Depovernil, Quinoseptyl, Spofadazin, Sulamin, Sulfamethoxypyridazine etc.; joint venture. B) — chemotherapeutic means from group of sulfanamide drugs. 6 (n-Aminobenzolsulfamido) - 3-metoksipiridazin; With 11 H 12 N 4 O 3 :
White crystal powder with a yellowish shade, inodorous, bitterish taste. Let's badly dissolve in a cold water, we will well dissolve in hot alcohol, the diluted alkalis and to-takh.
On a range and the mechanism of antimicrobic action it is similar to other sulfanamide drugs (see). Treats group of sulfanamide drugs of long action. It is quickly soaked up from went. - kish. a path, well gets through hematoencephalic and placental barriers, gets into pleural and belly cavities, collects in bile. After intake in the maximum concentration collects in blood in 3 — 6 hour. Out of an organism it is brought slowly. Time of semi-removal makes apprx. the 35th hour. S.'s allocation happens through kidneys. In urine drug is defined in not changed look (30 — 60%) and in an acetylized form (40 — 70%). Content in urine of a large amount of drug in an acetylized form causes a possibility of a crystalluria, for the prevention a cut it is necessary to adhere to strictly recommended scheme of treatment and to appoint plentiful alkaline drink.
Apply for treatment of bacterial upper respiratory tract infections and lungs (laryngitis, bronchitis, focal pneumonia), infections of an ear, throat, nose (purulent otitis, tonsillitis, pharyngitis, sinusitis), acute dysentery, inf. diseases zhelche-and urinary tract. The page is also means of the choice for treatment of purulent meningitis, including meningococcal. At trachoma, and also at local purulent infections (purulent wounds, abscesses, furuncles, osteomyelitis) apply well water soluble Sulfapyridazinum-nat-ry, to-ry is sodium
salt C. C. appoint inside. The daily dose is accepted in one step. At severe forms of bacterial infections, and including at purulent meningitis, in the first day appoint adult 2 g, in the next days — on 1 g a day. At easy and medium-weight forms of bacterial infections in the first reception give 1 g, in the next days — on 0,5 g a day. To S. children appoint at the rate of 25 mg/kg in the first days and 12,5 mg/kg in the next days.
Sulfapyridazinum sodium is applied locally. For treatment of trachoma solutions of drug for 5 — 7% solution of polyvinyl alcohol use 10 — 20%. Apply to treatment of local purulent infections 3 — 5 — 10% solutions on a distilled water, isotonic solution of sodium chloride or on solution of polyvinyl alcohol. At trachoma solution Sulfapyridazinum sodium is dug in in a conjunctival sac on 2 drops by 2 times a day within 30 days. Topical treatment is combined with S.'s reception inside. At local purulent infections solutions apply Sulfapyridazinum sodium to irrigation of wounds, treatment of bandages and tampons. Bandagings make daily or in 1 — 2 day within 7 and more days. At hron. purulent processes in lungs and bronchial tubes appoint inhalations of 10% of solution Sulfapyridazinum sodium (on 5 ml to inhalation 2 times a day within 7 — 10 days). Inhalations combine with S.'s reception inside.
Possible side effects at S.'s use same, as well as at use of other sulfanamide drugs (allergic reactions, dispeptic frustration, a leukopenia, etc.).
Forms of release: powder; tablets on 0,5 g. For treatment inf. diseases of eyes Sulfapyridazinum sodium is released in the form of the eye films containing 5 — 5,5 mg of drug, to-rye pack 30 pieces into plastic cases or hermetically the corked glass bottles. Store in the place protected from light.
Bibliography: Padeysky E. N and Polukhina JI. M. New sulfanamide drugs of long action for treatment of infectious diseases, page 9, etc., M., 1974; JI semi-cinchona. M, Padeyskaya E. N. ipershin G. N. Results of studying of pharmacokinetics of depot streptocides in an experiment and clinic, in book: Pharmacokinetics and metabolism of medicines, under the editorship of T. S. Safonova and V. A. Chernov, page 136, M., 1978.
L. D. Shipilova.