From Big Medical Encyclopedia

SULFANYLUREA (synonym: sulfamochevina, N-Sulfanilcarbamidum) — n-Aminobenzolsulfanil-mochevina, 4-H 2 NC 6 H 4 SO 2 NHC(O)NH 2  ; treats streptocides, in a wedge, to practice as medicine apply monohydrate of sulfanylurea. The page is basic substance for synthesis of group of gipoglikemiziruyushchy streptocides, so-called group of drugs of sulfanylurea (see. Gipoglikemiziruyushchy means ), to the Crimea carry Butamidum (see), bukarban (see), Cyclamidum (see), Chlorproramidum (see), hlotsiklamid (see), etc.

S. represents white crystal powder, inodorous; pier. the weight (weight) 215, t°pl 146 — 148 ° (with decomposition), crystallizes from water, t°pl of monohydrate of Page 125 — 127 °. The page is not enough rastvorim in water, is difficult dissolved in alcohol, it is easy — in divorced acids and caustic alkalis. Receive S. by boiling of streptocide with urea (see) in the presence of Na2C03 sodium carbonate. Page of a malotoksichn.

Page it is especially effective concerning Staphylococcus and E. coli, it is quickly and fully soaked up from went. - kish. path. It is allocated from an organism preferential through kidneys, high concentration of not changed S. in urine provides its antibacterial action on contagiums of uric ways. S.'s deposits in uric ways were not observed.

S.'s monohydrate under the name «Urosulfanum» [Urosulfanum, a synonym: Euvernil, Sulfacarbamidum, Uramid (V), etc.] apply as medicine at cystitis, pyelites, tsistopiyelita, pyelonephritises and other infections of uric ways; S.'s monohydrate at pyelites and cystitis without disturbance of urination is especially effective.

Drug is appointed inside on 0,5 — 1 g of 3 — 5 times a day. An average dose for adult 3 g a day. Course of treatment from 6 to 12 — 14 days. The daily dose for children distributed on 4 — 5 receptions makes 1 — 2,5 g the Highest doses for adults inside: one-time — 2 g, daily — 7 g.

Form of release: powder and tablets on 0,5 g, storage in well corked container, the joint venture. B.

See also Sulfanamide drugs .

Bibliography: Mashkovsky M. D. Pharmaceuticals, p. 2, page 227, M., 1977; Melentyeva G. N. Pharmaceutical chemistry, t. 1, page 314, M., 1976; Dictionary of organic compounds, ed. by I. M. Heilborn a. o., v. 5, p. 2930, L., 1965; Leitch L. Page, B a k e of V. of E. a. Brickman L. Synthesis of sulfanily-thiourea and related compounds, Canad. J. Res., v. 23B, p. 139, 1945.

H. G. Budkovskaya.