SULFAMONOMETHOXINUM (Sulfamonomethoxinum; synonym: Daimeton, Sulfamonomethoxine) — chemotherapeutic means from group of sulfanamide drugs. 4 (n-Aminobenzolsulfamido) - 6-metoksipirimidin; With 11 H 12 N 4 O 3 S:
Crystal powder, white or white with creamy shade. We will dissolve in water a little, we will well dissolve in the diluted solutions of alkalis and mineral to - t. On a range and the mechanism of antibacterial action it is similar to others to sulfanamide drugs (see). Is one of the most active sulfanamide drugs of long action. At intake it is quickly soaked up from went. - kish. a path also collects in blood in the maximum concentration in 2 — 3 hours after introduction. Communicates proteins of plasma for 64 — 92%. Well gets through fabric barriers, and at inflammatory processes in covers of a brain — and through a blood-brain barrier. The elimination half-life makes the 30th hour of blood. Out of an organism it is brought through kidneys. During 3 days about 70 — 80% of the entered dose are allocated. With urine C. it is removed partially in not changed look (20%), in the form of a glucuronide (30%) and acetyl derivative, a cut it is better rastvorimo, than Page. At prolonged use does not kumulirut.
Apply for treatment of the bacterial infections caused by microorganisms, sensitive to streptocides, napr at respiratory infections and nasopharynxes, infections to urine - and biliary tract, purulent wound fevers, pustulous diseases of skin, a spotted fever (medium-weight forms of a disease in the absence of vomiting and disturbance of swallowing), the gonorrhea caused by strains of a gonokokk, steady against antibiotics. Apply to treatment of malaria and nek-ry other protozoan diseases of S. usually in combination with Trimethoprimum.
Appoint inside. The daily dose is usually given in one step, sometimes — in 2 — 3 receptions. The adult in the first day appoint 1 — 2 g, in the next days 0,5 — 1 g. To children in the first day drug is appointed at the rate of 25 mg/kg, in the next days — 12,5 mg/kg. At treatment of a meningococcal infection of a dose respectively increase twice. At the gonorrhea caused by strains, steady against antibiotics, adults in the first 2 days are given 1,5 g 3 times a day, then — on 1 g 3 times a day within 3 days, but no more than 18 g on a course of treatment.
The page can cause the same side effects, as well as other streptocides (allergic reactions, dispeptic frustration, etc.).
Form of release: tablets on 0,5 g. Store in the place protected from light.
Bibliography: Padeysky E. N and Polukhina L. M. New sulfanamide drugs of long action for treatment of infectious diseases, page 81, M., 1974.
E. N. Padeyskaya.