SULFAGUANIDINE (Sulginum; synonym: Abiguanil, Guamid, Neosulfonamid, Resulfon, Sulfaguanidinum etc.; GFH, joint venture. B) — chemotherapeutic means from group of streptocides. n-Aminobenzolsulfanil-guanidin; With 7 H 10 N 4 O 2 S:
Inodorous white fine-crystalline powder, we will dissolve in water and solutions of alkalis very little, it is a little alcohol-soluble also acetone, with divorced salt and nitric to-tami forms water soluble salts; pier. weight (weight) 232,26; t°pl 189 — 192 °.
On a range of antibacterial activity corresponds to other sulfanamide drugs (see) and it is active concerning intestinal group of bacteria, streptococci, diplococcuses, etc.
It is slowly soaked up from went. - kish. a path in this connection collects in intestines. In blood it is found in concentration to 5 mg on 100 ml.
Apply at intestinal infections (acute, subacute and hron. bacillar dysentery, etc.), and also at a carriage of dysenteric sticks and sticks of a typhoid, for preparation for operations on intestines.
At acute intestinal infections of Page. appoint inside the adult on 1 — 2 g on reception according to the following scheme: 6 times in the 1st days, on 5 times in the 2nd and 3rd days, 4 times in the 4th, 3 times in the 5th days.
For treatment of acute dysentery sulfaguanidine is appointed in the same doses and according to the same scheme, as Ftalazolum (see).
The highest doses for adults inside: one-time 2 g, daily 7 g.
Along with S. at treatment of intestinal infections it is reasonable to appoint well soaking up from went. - kish. path streptocides, napr, Sulfadimezinum, Etazolum, etc. In need of S. it is possible to appoint in a combination with antibiotics.
At S.'s intestines operations each 8 hours within 5 days before operation and in the same dose within 7 days after operation appoint from calculation for 0,05 g/kg.
The page can cause the same side effects, as other sulfanamide drugs (nausea, vomiting, headaches, a leukopenia, etc.)*. In order to avoid development of by-effects from uric ways (loss of crystals of an atseta of lirovanny S.) during treatment appoint alkaline drink (2 — 3 l a day). Besides, it is necessary to give to patients sufficient doses of vitamins of group B since S. oppresses growth of colibacillus and thereof reduces synthesis in intestines of the specified vitamins.
Form of release: powder, tablets on 0,5 g. Storage: in well corked container.
T. N. Sizova.