STREPTOCIDE (Streptocidum; synonym: streptocide white, Streptocidum album, Sulfanilamidum etc.; GFH, joint venture. B) — chemotherapeutic means from group of streptocides, n-Aminobenzolsulfanilamid, or sulphamid; With 6 H 8 N 2 O 2 S:
Inodorous white crystal powder. We will dissolve in a cold water a little, we will easily dissolve in a boiling water, divorced salt to - those, solutions of caustic alkalis and acetone, it is difficult alcohol-soluble, it is practically not ether-soluble also chloroform; pier. weight (weight) 172,21; t ° pl 164 — 167 °. As well as other sulfanamide drugs, S. is active concerning stafilokokk, streptococci, meningokokk, gonokokk, pneumococci, colibacillus and nek-ry other bacteria. It is well soaked up from went. - kish. a path, apprx. 90 — 95% of the accepted S. quickly it is removed with urine, both in not changed look, and in the form of acetylized products.
Apply for treatment of an ugly face, inf. dermatosis, quinsy, cystitis, pyelitis and others inf. the diseases caused by flora, sensitive to streptocides. Appoint inside the adult 0,5 — 1 g to reception in each 4 — 6 hours (only 3 — 6 g a day); to children aged till 1 year on 0,05 — 0,1 g, from 2 to 5 years on 0,2 — 0,3 g, from 6 to 12 years on 0,3 — 0,5 g on reception.
The highest doses for adults inside: one-time 2 g, daily 7 g.
At superficial inf. damages of skin and mucous membranes, burns, contaminated wounds, ulcers, etc. S. apply locally in the form of 5 and 10% of streptotsidovy ointment (Unguentum Streptocidi) or 5% of Linimentum Streptocidi (Linimentum Streptocidi), the containing streptocide of 5 g, fish oil of 34 g, emulsifier, the stabilizer and the water distilled to 100 ml.
Usually bring the smallest sterile powder C. in a wound (on 5 — 10 — 15 g) and at the same time appoint inside streptocides or other antibacterial drugs.
For treatment acute and hron. rhinitises sometimes use Suno-ref ointment (Unguentum «Sunoreph») containing S., Norsulfazolum and Sulfadimezinum on 5 g, ephedrine of a hydrochloride of 1 g, camphor of 3 g, eucalyptus oil of 5 drops, an ointment basis to 100 g.
Side effect The page is shown by headaches, dizziness, nausea, vomiting. At prolonged use development of a leukopenia, agranulocytosis, dermatitis, paresthesias, cyanosis is possible.
It is contraindicated at diseases of the hemopoietic system, nephrites, nefroza and a hyperthyroidism.
Form of release: powder; tablets on 0,3 and 0,5 g; 5 and 10% ointment in glass jars on 25 g; 5% linimentum in tubas or glass jars on 30 and 50 g. Storage: in well corked container in the place protected from light.
In medical practice it is used also Streptocidum solubile (Streptocidum solubile; GFH, joint venture. B), to-ry in the chemical relation n-sulfamido-benzolaminometansulfatom of sodium is; With 7 H 9 N 2 NaO 5 S 2 :
White crystal powder. Let's dissolve in water, we will practically not dissolve in organic solvents. Water solutions will sterilize at t ° 100 ° within 30 min.
Indications to appointment the same that at S. Naznachayut's use parenterally and inside. For hypodermic and intramuscular introduction solutions use 1 — 1,5%, to-rye prepare on water for injections or isotonic solution of sodium of chloride. The specified solutions enter in quantity up to 100 ml 2 — 3 times a day. Intravenously enter 20 — 30 ml 2 — 5 — 10% of the solution prepared on water for injections, isotonic solution of sodium of chloride or 1% solution of glucose.
Inside the Streptocidum solubile is appointed in the same doses, as streptocide.
Form of release: powder. Storage: in well corked container.
See also Sulfanamide drugs .
T. N. Sizova.