SPHAEROPHYSINUM (Sphaerophysinum) — ganglioblokiruyushchy means; alkaloid of a sferofiza saline (Sphaerophysa salsula, Pall) this. bean (Leguminosae), growing in Central Asia, in the Caucasus, in Western Siberia.
In medical practice apply Sphaerophysinum benzoate (Spaerophysini benzoas, synonym of Sphaerophysinum benzoicum; GFH, joint venture. Б). I-Guanidino-4-(izoamilen - I - silt-амино) - butane dibenzoate; With 20 H 22 N 4 - 2C 7 H 6 O 2 .
Inodorous white crystal powder, bitterish taste. Let's easily dissolve in water, 95% alcohol and solutions of caustic and carbonic alkalis, it is practically not ether-soluble also chloroform; t°pl 151 — 153 °; pier. weight (weight) 442,6. Water solutions will sterilize at t ° 100 ° within 30 min.
S. has ganglioblokiruyushchy effect and causes decrease in the ABP. Blocks also N-holinoretseptory of a sinocarotid zone and chromaffin tissue of adrenal glands. Against the background of its action the pressor effect amplifies adrenaline (see). Besides, S. raises a tone and sokratitelny activity of a myometrium.
Apply The page is preferential as uterine means for stimulation of patrimonial activity, a stop of bleedings in a puerperal period and at an atony of a uterus (see. Uterine means ). Women in labor with the raised ABP can appoint page. As the antihypertensive at arterial hypertension is practically not used since on activity in this respect concedes to other antihypertensives.
For an odynagogue of S. usually enter subcutaneously or intramusculary on 1 ml of 1% of solution in each hour. In total do 6 injections. With the same purpose drug is appointed sometimes inside on 0,03 g in 2 hours. According to other testimonies of S. appoint inside 0,03 g 2 — 3 times a day or parenterally on 1 ml of 1% of solution 2 — 3 times a day.
The highest doses inside: one-time 0,05 g, daily 0,1 g
of S. can cause side effects, inherent to other ganglio-blockers, e.g. orthostatic hypotension, ^ decrease in secretion of excretory glands, etc.
Contraindications same, as at use of other ganglioblokator (hypotonia, the expressed atherosclerosis, organic lesions of a myocardium).
Form of release: powder. Storage: in well corked banks of orange glass, in the place protected from light.
See also Ganglioblokiruyushchy means .
E. Yu. Lemina.