SOVKAIN (Sovcainum; synonym: Butylcaine, Cincain, Cinchocaini hydrochloridum, Nupercain, Percaine etc. GFH; joint venture. A) — mestnoanesteziruyushchy means. beta Diethylaminoethyl of amide 2-butoksitsinkhoninovy to - you are a hydrochloride; With 20 H 29 N 3 O 2 - HCl:
Inodorous white crystal powder. It is hygroscopic. Let's very easily dissolve in water, we will easily dissolve in 95% alcohol, acetone and chloroform, it is almost insoluble on air; pier. weight (weight) 379,93. Solutions C. will sterilize at t ° 100 ° within 30 min. For stabilization of solutions C. to them add solution salt to - you (to pH 3,5 — 4,2). The page is 15 — 20 times more active than novocaine (see). Duration of action of S. same, as Trimecainum (see) and xycain (see), and 3 times more, than novocaine. However S. by 15 — 20 times toksichny novocaine, by 10,7 — 16,6 times toksichny Trimecainum and by 7,5 — 13 times toksichny a xycain. The page concedes to Trimecainum and to a xycain on the width of therapeutic action is more slowly brought out of an organism.
Page. apply generally for spinal anesthesia. For this purpose it is entered into the spinal canal in the form of 0,5 — 1% of solution, in number of 0,8 — 0,9 ml (adult). For the purpose of the prevention of falling of the ABP previously enter subcutaneously 1 ml of 5% of solution of ephedrine. The highest single dose for adults at introduction to the spinal channel of 0,01 g (once).
At S.'s intoxication pallor, cyanosis, a cold snap of extremities, falling of the ABP, a faint, bradycardia, weakening of cordial activity and breath are noted. In this case sodium, and also symptomatic means depending on a picture of intoxication enter under skin ephedrine, caffeine-benzoate. To page it is contraindicated to children up to 8 years, in geriatric practice, at cardiovascular insufficiency, hypotension, abnormal liver functions and kidneys.
Forms of release: powder, ampoules on 1 ml of 0,5 and 1% of solution. The page is also a part of the aerosol drugs «Legrazol» and «Tegralezol».
Store with precaution, in well corked banks of orange glass.
See also Anesthetics .
Bibliography: The pharmacological basis of therapeutics, ed. by A. G. Gilman a. o., N. Y. 1980.
H. T. Pryanishnikova.