SORBITE

From Big Medical Encyclopedia

SORBITE (C 6 H 14 O 6  ; synonym sorbitol, D-glyutsitol) — hexatomic alcohol, product of recovery of D-glucose.

The page represents colourless crystals of sweet taste, well water soluble, hot and cold alcohol and almost soluble in absolute alcohol, gpl anhydrous sorbite 104 — 110 °, [a]D = — 1,7 ° (in water). The page does not recover liquid of Felinga, reacts, characteristic of polyatomic alcohol, is oxidized to sugar to - you, bacteria is oxidized to L-sorbose.

Receive S. oxidation of D-glucose. Quantitatively S. define by peryodatny oxidation (see. Titrimetric analysis ). At animal S.' number is an intermediate product at synthesis of ascorbic acid (see) from glucose (see). In a human body of S. is oxidized enzyme, organospetsifichny for a liver — sorbitol dehydrogenase (L-iditoldegidrogenazoy; KF 1.1.1.14) to D-fructose, edges then joins in glycolysis (see).

The page is formed in tissues of mammals as fiziol. metabolite. Comes to a human body of S. with fruit and berries (apples, pears, apricots, peaches, a mountain ash, a cornel, a hawthorn, etc.). Fruits of a mountain ash and a blackthorn are especially rich with it. At storage of fruits and berries C. gradually turns into fructose.

In food of the person drugs C. are used as sweet substance (see). Its sweet is approximately twice lower, than glucose. S.'s caloric content is equal to 3,4 kcal/g. In intestines it is soaked up much more slowly than glucose. At peroral introduction to 3% of sorbite it is brought out of an organism with urine in not changed look; at parenteral administration its excretion with urine can be much higher. A small amount of S. (25 — 35 g a day) at peroral introduction does not cause a hyperglycemia. The page assimilates liver without participation of insulin therefore it is applied in food of patients with a diabetes mellitus (see a diabetes mellitus); besides, it is used as substitute of sugar in prevention and treatment of obesity (see). Replacement in a diet of sugar by S. promotes nek-rum to reduction of caries (see. Caries of tooth ).

The village has cholagogue and aperient properties, however they are expressed more weakly, than at xylitol (see).

S.'s use as a component of a number of dosage forms is known (elixirs, mixtures, emulsions, etc.). Villages use also for production of ascorbic acid, sorbose and as a component of a medium at cultivation of nek-ry microorganisms.



Bibliography: Kryshen P. F. and Rafes Yu. I. Sorbit, xylitol, glycerin and their use in medicine, Kiev, 1979; The Reference book on dietology, under the editorship of. And. and! Pokrovsky and M. A. Samsonov, M., 1981; Limits on infusions of laevulose and sorbitol, by the Australian drugs wolution committee’ Med. J. Aust., v. 1, p. 582, 1976.

V. A. Konyshev; V. K. Gorodetsky (biochemical).

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