SOLUSURMINUM (Solusurminum; synonym: Antilicon, Myostibin, Natrii stibogluconas, Pentostam, Sodium stibogluconate, Solustibosan, Solu-stin, Stibanate, Stibanose, Stibatin, Stibinol, Stibogluconat-Natrium etc.; joint venture. B) — protivoleyshmaniozny means. Sodium salt of complex compound of pentavalent antimony and gluconic to - you;
Inodorous hygroscopic powder, white or white with yellowish shade, slowly water soluble; insoluble, in organic solvents. Content of metal antimony in drug fluctuates from 21 to 23%. Water solutions of a termostabilna also maintain sterilization in the autoclave at t ° 110 ° within 30 min.
Mechanism of action Page on a leushmania it is caused, apparently, by the ability which is contained in it antimony (see) to inactivate fermental systems of the activator due to covalent binding of their sulphhydryl groups that breaks processes of metabolism of the activator and leads to his death.
The page quickly is completely soaked up at parenteral administration, collecting in the highest concentration in a spleen and a liver.
Pages apply at visceral leushmaniosis (see), and also at a tuberculoid form of a skin leushmaniosis. Usually S. enter intravenously in the form of 20% of solution. At impossibility of intravenous administration the specified solution is entered under skin. However subcutaneous injections are very painful and can be followed by formation of infiltrates.
At treatment of a visceral leushmaniosis the daily dose of S. makes from 0,1 to 0,15 g, course — from 1,4 to 1,8 g. The daily and course dose is established depending on age and the body weight of the patient (tab. 1).
To children the daily dose is entered in one step, the adult — in two steps (in the morning and in the evening). Injections do daily. Treatment of patients is begun with doses, equal 1/3 full daily doses, gradually (through 3 — 4 injections) increasing it to full daily. The course of treatment makes from 1,5 to 3 weeks. In case of earlier a wedge, recovery it is possible to stop S.'s introduction, continuing dispensary observation for the patient within 2 — 4 months. In case of a palindromia the course of treatment is repeated.
At a tuberculoid form of a skin leushmaniosis of S. appoint in other doses (tab. 2.).
The drug is administered daily, beginning treatment with 1/3 — 1/4 full daily doses and gradually increasing it to full daily. Duration of a course of treatment is 3 — 4 weeks. At palindromias carry out repeated courses of treatment with a break of 2 months.
At S.'s reception side effects in the form of nausea, cough, a headache, dizziness, weakness are possible; a small tortoiseshell, bleeding of gums is sometimes observed.
At emergence of symptoms hron. intoxications appoint Unithiolum (see) and a symptomatic treatment.
Page. it is contraindicated at hypersensitivity to drugs of antimony, accompanying acute inf. diseases, the expressed dystrophy, intoxications, and also at a serious illness of cardiovascular system and a liver.
At a visceral leushmaniosis when drug is appointed according to vital indications, contraindications do not consider.
Forms of release: ampoules on 10 ml of a 20%r-r; powder in bottletight bottles. Store in the place protected from light at the room temperature.
The table 1 DAILY AND COURSE DOSES of SOLUSURMINUM AT the VISCERAL LEUSHMANIOSIS
Table 2 DAILY AND COURSE DOSES of SOLUSURMINUM AT the TUBERCULOID FORM, the SKIN LEUSHMANIOSIS
N. Yu. Moskalenko.