From Big Medical Encyclopedia

SEYNTA SYNDROME (Saint, sovr. South African pathologist; synonym Seynt's triad) — combination of cholelithiasis to phrenic hernia and divertuculosis of a large intestine. Admits not all researchers.

It is described in 1948 by Müller (Page J. Century of Muller) who suggested to call it Seynt's triad (in honor of the scientist who for the first time paid attention to a combination of these diseases).

Apparently, this three types of pathology are combined not accidentally. According to Bertrán and Le Goaran (J. Bertrand, P. Le Goarant, 1975), at the persons suffering from a divertuculosis of a large intestine, other components C. of page are found in 17,7% of cases, at phrenic hernia — in 25,4%; according to Foster and Natson (J. J. Foster, D. L. Knutson, 1958), at the patients who transferred a cholecystectomia concerning cholelithiasis — in 19% of cases. The age of patients with S. is higher than page, than the persons suffering from one of the diseases which are a part of a syndrome and are averaged by 68 years. At S. the page often observe locks. Believe that locks, causing increase in intra intestinal pressure, promote development of a divertuculosis of a large intestine and phrenic hernia, and accompanying biliary staz can play an important role in development of cholelithiasis. At women with S. the page often note obesity. And though at men of it it is not observed, nevertheless attach to obesity pathogenetic significance. A number of researchers indicates a role of inborn weakness of the mesenchymal fabric causing further dystrophic changes of smooth muscles of a large intestine, a diaphragm and bilious ways. There is an opinion that the hypothyroidism which is followed by a hypercholesterolemia, decrease in a muscle tone and locks can become S.'s reason for page.

Pathoanatomical changes represent a combination of the changes characteristic of cholelithiasis, phrenic hernia and divertuculosis of a large intestine (see. Diaphragm , Cholelithiasis , Intestines ). In a wedge, a picture approximately at 2/3 patients symptoms of cholelithiasis, at 1/3 — phrenic hernia prevail, the divertuculosis of a large intestine proceeds asymptomatically.

Diagnosis is based on a combination of symptoms of cholelithiasis and phrenic hernia, and also identification of a divertuculosis of intestines.

Treatment comes down to therapy of each disease which is a component C. of page.

Forecast depends on the course of the diseases making a syndrome.

Bibliography: Vasilenko V. of X. and Grebenev A. JI. Hernias of an esophageal opening of a diaphragm, M., 1978; With to at I N. A. Diseases of a holangio-duodeno-pancreatic zone, Riga, 1981, bibliogr.; Bertrand J. et Le Goarant P. La triade de Saint, Rev. franc. Gastroent., t. 108, p. 15, 1975; Foster J. J. a. Knutson D. L. Association of cholelithiasis, hiatus hernia, and diverticulosis coli, J. Amer. med. Ass., v. 168, p. 257, 1958; Muller C. J. B. Hiatus hernia, diverticula and gall stones, Saint’s triad, S. Afr. med. J., v. 22, p. 376, 1948; Palmer E. D. Saint’s triad. (hiatus hernia, gall stones and diverticulosis coli), problem of properly directing surgical therapy, Amer. J. dig. Dis., v. 2*2, p. 314, 1955.

A. V. Frolkiye.