From Big Medical Encyclopedia

SEROTONINOPEKSIYA — the phenomenon of binding of free serotonin (5-gidroksitriptamin) serum proteins and nek-ry cells, is one of mechanisms of an inactivation of serotonin in an organism. S.'s intensity can serve as an additional indicator both at diagnosis of allergic diseases, and at assessment of expressiveness of allergic process and efficiency of treatment though S.'s definition did not find broad application in clinic. Thanks to S. and some other biol. mechanisms in an organism the optimum level physiologically active, i.e. free is supported, serotonin (see). The connected serotonin loses the fiziol. activity. Increase in content of free serotonin in blood in comparison with norm at S.'s oppression leads to sharp fluctuations of the ABP, development bronchospasm (see), to disturbance of cordial activity. For the first time S. was described in 1959 Paro (J. L. Parrot), etc.

The main serum proteins connecting serotonin are albumine (see): believe that 1 molecule of albumine is capable to connect to 11 molecules of serotonin. Mast cells, cells of tissues of lungs, liver, erythrocytes and especially thrombocytes (see) also have ability to connect serotonin though the nature of binding of serotonin thrombocytes differs by nature binding in its blood proteins. Absorption of serotonin cells of an organism is the volatile process interfaced to transport of ions of Na + and K+. So, decrease in ion concentration of Na+ and furthermore their total absence sharply oppresses binding of serotonin cells. Lack of ions of K+ slows down binding of serotonin for 30 — 40%. Decrease in concentration of ATP, reduction of intensity of energy balance, an anoxia reduce serotoninpeksichesky properties of the corresponding cells.

Intensity of binding of serotonin is quantitatively determined by the size of a so-called serotoninpeksichesky index (SPI). Normal, according to a spectrophotometric method, it makes 30 — 40% (50 mkg of serotonin added to 1 ml of dialyzed blood serum communicate it for 30 — 40%). SLEEP define also by intracutaneous tests, i.e. enter solution of the serotoninkreatinsulfat mixed and incubated with a blood plasma of investigated vnutrikozhno. Control is intradermal introduction of 0,2 ml of mix from 0,1 ml of 0,1% of solution of a serotoninkreatinsulfat and 0,1 ml of isotonic solution of sodium chloride. Make an intradermal injection of 0,2 ml of isotonic solution of sodium chloride for definition of normal reactivity of skin. In 20 min. determine the area of erubescence in places of pricks. At negative reaction the area of the erubescence caused by an intradermal injection of mix of a blood plasma of the serotoninkreatinsulfat investigated with solution is less than the area of reddening in the place of an injection of mix of solution of a serotoninkreatinsulfat with isotonic solution of sodium chloride. At positive reaction of the area of erubescence in both cases are identical. At sharply positive reaction the area of erubescence in the place of an injection of a blood plasma investigated, incubated with solution of a serotoninkreatinsulfat, is more than the area of erubescence in the place of an injection of mix of solution of a serotoninkreatinsulfat with isotonic solution of sodium chloride. SLEEP can change a little depending on a functional condition of an organism. At allergic diseases, especially at allergic reactions of immediate type (see. Allergy ), S. sometimes decreases to zero that demonstrates decrease in protective forces of an organism. At specific desensitizations (see) or nonspecific therapy of allergic diseases lexical properties of serum proteins and cells increase. The resort therapy having allergic diseases has the normalizing effect on exchange of serotonin and a serotoninpeksiya.

Bibliography: Dagilis P. Yu., Kondrataye P. V. and Tsibas P. B. Indicators of serotonin and a serotoninopeksi-chesky index at a balneoterapiya of rheumatism and a pseudorheumatism, in book: An allergy and reactivity of an organism, under the editorship of T. V. Mitina, etc., t. 2, page 229, M. — Lviv, 1969; Semenovich. And. and d river Serotoninopeksiya, Laborat. business, No. 3, page 140, 1966; Yurenev P. N. and d river. To a question of the mechanism of lexical properties of blood serum, Owls. medical, And, page 19, 1971; Flavian N., S ain-d e 1 1 e A. et Parrot J. L. Captation de la 5-hydroxytryptamine par les globules rouges humaines normaux, Page R. Acad. Sci. (Paris), t. 263, p. 576, 1966; F u r a-n o A. V. a. G of e e n J. P. The uptake of biogenic amines by mast cells of the rat, J. Physiol, (bond.), v. 170, p. 263, 1964; H a-r u n a H. o. Studies on histaminopexy and serotoninopexy in normal and in asthmatic children, Jap. J. Allergy, v. 17, p. 874, 1968; Innes I. R. Uptake of 5-hydroxytryptamine and adrenaline in the liver, Brit. J. Pharmacol., v. 21, p. 202, 1963; To e of p L. u. K a s e m i r H. Zur Bindung von 5-hydroxytryptamine durch serum proteines, Naunyn-Schmiedeb erg’s Arch. exp. Pharmak., Bd 243, S. 187, 1962; Parrot J. L. e t Flavian N. Captation de la 5-hydroxytryptamine par le serum humain normal, Absence de cette captation chez les sujects allergiques, C. R. Acad. Sci. (Paris), t. 249, p. 463, 1959.

P. B. Tsibas.