SECURININUM (Securininum) — the stimulator of the central nervous system which is contained in elevated parts of a sekurinega of semi-shrubby (Securinega suffruticosa Pall) this. a spurge family (Euphorbiaceae), growing hl. obr. in the Far East and in Siberia, and also cultivated in the southern regions of the USSR. S.'s maintenance in various parts of a plant makes 0,1 — 0,4%.
In medical practice use Securininum nitrate (Securinini nitras; synonym Securininum nitricum; GFH, joint venture. A); With 13 H 15 NO 2 - HNO 3 :
Inodorous crystal powder, white or white with creamy or pinkish shade. Under the influence of light turns pink. Let's dissolve in water, we will difficult dissolve in 95% alcohol; t pl 200 — 205 ° (melts with decomposition); pier. weight (weight) 280,28. Has exciting effect on c. the N of page, increases reflex irritability of a spinal cord and a muscle tone, strengthens breath and cordial activity. In toxic doses causes tetanic spasms in animals. On the nature of action it is close to to strychnine (see), but is less active and by 8 — 10 times is less toxic.
Apply at paresis and sluggish paralyzes, including after the postponed poliomyelitis (in the recovery period of a disease) and as tonic at various neurotic and psychasthenic states, and also at impotence because of functional psychological frustration.
Appoint inside on 0,002 z or in the form of 0,4% of solution on 10 — 20 drops 2 — 3 times a day within 20 — 30 days. The highest doses for adults inside: one-time 0,005 g, daily 0,015 g; under skin: one-time 0,003 g, daily 0,005 g.
It is contraindicated at a hypertension, bronchial asthma, atherosclerosis, stenocardia, nephrite, hepatitis, pregnancy, a thyrotoxicosis and bent to convulsive reactions.
Forms of release: tablets on 0,002 g and 0,4% solution (for intake) in bottles on 15 ml. Storage: in well corked banks of orange glass in the dry, protected from light place.
See also Neural activity stimulators .
S. Ya. Sokolov.