From Big Medical Encyclopedia

SEBORRHEA (seborrhoea; lat. sebum fat + Greek rhoia expiration; synonym seborrhagia, steatorrhoea) — the morbid condition of skin caused by the increased allocation by sebaceous glands of skin fat of the changed chemical composition.

Beytmen (Th. Bateman, 1817) for the first time noted the increased greasiness of skin at youthful eels; the term «seborrhoea» was entered in 1840 by G. Fuchs.

The page most often arises aged from 12 up to 24 years. According to Coen (E. Cohen, 1945), it is observed at 57% of men and at 46% of women aged from 17 to 21 g. The functional nervous and endocrine disturbances arising during the period are the reason of development of S. puberty (see). As a result of age changes of functions of a front share of a hypophysis, cortical substance of adrenal glands and gonads both at men, and at women contents in an organism of androgens increases. Owing to disturbances from nervous and endocrine systems develop a hyperplasia and gipersekreshchsh sebaceous glands (see), the chemical composition, a consistence and biological properties of skin fat changes, the strengthened keratinization of epithelial cells and disturbance of normal removal of fat from sebaceous glands is noted.

S.'s current is made heavier by diseases went. - kish. path (gastritis, peptic ulcer, colitis, etc.), hron. centers of an infection (hron. tonsillitis, antritis, otitis), hypovitaminoses, especially And yes With, and also pollution of skin.

Patogistologiya: the diffuse and follicular hyperkeratosis is observed (see. Keratoza ), the strengthened keratinization of cells of output channels and a sharp hyperplasia of sebaceous glands; in a derma (see. Skin ) around follicles of hair and sebaceous glands there is a limfogistiotsitarny infiltrate; at a part of patients keratinaceous transformation of cells of sebaceous glands is noted.

The first signs of S. are sharp strengthening of sebaceous secretion on face skin, especially in nososhchechny (nosokrylny) folds, skin of a pilar part of the head, a back, a breast. Skin of these sites shines from a large amount of skin fat, hair grease, stick together in a lock. Mouths of follicles of hair and output channels of sebaceous glands are expanded (porosity of skin) and are quite often corked grease and horn up — a comedone. Further at sick S. such complications as an atheroma can develop (see. Epidermoid cyst ), vulgar eels (see), erythematic and squamous defeats of a pilar part of the head of type dandruff (see) and seborrheal eczemas (see), pyoderma (see), seborrheal baldness (see. Alopecia ).

Back of the patient with dense seborrhea: widespread drain damage of skin in the form of comedones, atheromas, eels, hems.

F. Gebra distinguished fat and dry S. Nek-rye dermatologists continue to adhere to such classification. However by a number of researchers it is proved that so-called dry seborrhea is not connected with strengthening of sebaceous secretion; depending on a wedge, pictures it is diagnosed as dandruff, seborrheal eczema, seboreid (eritematoskvamozny scattered, are more often sites of defeat, roundish in a form) etc. Depending on a consistence of skin fat and character of the arising complications allocate the following forms fat, or true, to S.: liquid, dense and mixed. Liquid S. is characterized by more liquid, than normal, a consistence of skin fat and sharply strengthened sebaceous secretion. This form can proceed without emergence of vulgar eels. It has rather favorable current. By 20 — 25 years sebaceous secretion is normalized, acne rash is allowed. At dense S. sebaceous secretion is increased slightly, but more dense consistence of skin fat interferes with its free egress of skin that leads to development of numerous, including large comedones, atheromas and inertly proceeding eels, to-rye can remain up to 30 and more years, causing considerable cicatricial changes of skin (fig). The mixed S. is characterized by signs both dense, and liquid Page.

At treatment sick S. the means normalizing function of a nervous system and reactivity of an organism (drugs of bromine, calcium, neuroleptics, vitamins A, With, groups B), the nonspecific stimulating therapy, napr are recommended, autohemotherapy (see). According to indications apply estrogen and anti-androgens. Treatment of diseases is carried out went. - kish. path, sanitation of the centers hron. infections. Outwardly at uncomplicated S. appoint washings water solutions of 1 — 2% of sodium thiosulphate, borax, soda, potash alum; rubdowns by spirit solutions of folliculin, salicylic or boric to - t, a tannin; powders with sulfur, boric to - that; the shaken-up suspensions with sulfur or Ichthyolum. Uv and solar radiations, and also hydrotherapeutic procedures are shown.

Forecast, as a rule, favorable.

Prevention The page consists in careful observance of rules personal hygiene (see). For the persons inclined to S., regular rubdowns of face skin by spirit and water solutions of disinfecting substances, periodic reception of vitamin A, UF-radiation are recommended, hardening of an organism (see), treatment of the available diseases went. - kish. path and centers hron. infections, prevention of household and production pollution of skin.

Bibliography: Yu. F. Seborey's queens and eels, Minsk, 1972, bibliogr.; The multivolume guide to a dermatovenereology, under the editorship of S. T. Pavlov, t. 3, page 524, M., 1964; Fanta D. u. Niebau-e of G. Fortschritte der Medizin in Einzel-darstellungen, Wien. klin. Wschr., S. 677, 1977, Bibliogr.; Hurwitz S. Acne vulgaris, Current concepts of pathogenesis and treatment, Amer. J. Dis. Child., v. 133, p. 536, 1979, bibliogr.; Keller P. J. u. a. Behandlung von Akne und Seborrhoe mit Antiandrogenen, Schweiz, med. Wschr., S. 1640, 1978; Leyden J. J. Pathogenesis of acne vulgaris, Int. J. Derm., v. 15, p. 490, 1976; Plewig G. a. To 1 i gm an A. M. Akne, Pathogenese, Morphologie, Therapie, V. a. o., 1978; Rasmussen J. E. A new look at old acne, Pediat. Clin. N. Amer., v. 25, p. 285, 1978.

Yu. F. Korolev.