SALICYLAMIDUM (Salicylamidum; synonym: Algamon, Saliamid, Salopur etc.; GFH) — analgesic, febrifugal and anti-inflammatory drug. Amide salicylic to - you; With 7 H 7 NO 2 :
Inodorous white crystal powder. During the heating it is sublimated. We will dissolve in water very little, we will dissolve in 95% alcohol, ether, we will dissolve in chloroform a little; t ° pl 140 — 142 °, pier. weight (weight) 137,14.
On a chemical structure and pharmakol. to properties C. it is close to to acetylsalicylic acid (see) and to other salicylates. On activity concedes acetilsalicylic to - those, but it is better transferred since to a lesser extent irritates a mucous membrane went. - kish. path.
Page. apply as analgesic (e.g., at arthralgias, mialgiya, neuralgia, a headache, etc.), febrifugal and anti-inflammatory drug.
As analgesic and febrifuge C. apply inside 0,25 — 0,5 g 2 — 3 times a day to adults.
At rheumatism and other rheumatic diseases appoint inside in the first days 0,5 g 3 — 4 times a day, then on 1 g 3 — 4 times a day. If necessary and good tolerance of S. the daily dose can be brought to 8 — 10 g. To S. children appoint in a daily dose at the rate of 0,4 — 0,5 g to 1 year of life. Drug is accepted after food, washing down with a large amount of liquid.
The page causes same side reactions, as well as other salicylates (the sonitus, easing of hearing, dispeptic frustration, went. - kish. bleedings, allergic reactions, etc.). As well as other salicylates, S. is contraindicated at a peptic ulcer, portal hypertensia, venous stagnation and the lowered coagulability of blood.
Forms of release: powder and tablets on 0,25 and 0,5 g. Keep in well corked container in the place protected from light.
The page is a part of the candles of Tsefekon (Suppositoria «Cefeconum») containing 0,6 g of Salicylamidum on 0,2 g of pyramidon and acetphenetidiene, 0,05 g of caffeine or caffeine-sodium benzoate.
Bibliography: Mashkovsky M. D. Pharmaceuticals, p.1, page 180, M., 1977; N and with about N about in and V. A., etc. Pharmacotherapy in rheumatology, page 37, M., 1976; I with and N about in with to and y M. A., etc. Salicylates, M., 1975, bibliogr.; The pharmacological basis of therapeutics, ed. by A. G. Gilman and. lake, N. Y., 1980.
V. K. Muratov.