SALAZODIMETHOXINUM (Salazodimethoxinum) — chemotherapeutic means from group of sulfanamide drugs. 5-(n-[N-(2,4-Диметоксипиримидинил-6) - sulphamide] - fenilazo) - salicylic to - that; With 19 H 17 O 7 N 5 S:
Powder of orange color, without taste and a smell. It is water-insoluble, we will dissolve in solutions of alkalis and bicarbonates; pier. weight (weight) 459,45.
In the chemical relation of S. and close to it io to a structure Salazopyridazinum (see) and Salazopyrinum (a synonym Sulfasalazinum) are salazosulfanil-amides and differ from other sulfanamide drugs in existence of pharmakoterapevtichesky activity at nonspecific ulcer colitis. The therapeutic effect of S. and other salazosulfanilamid explain with selective accumulation them in connecting fabric (especially in a wall of a large intestine) and ability to stimulate reparative processes in a mucous membrane of intestines. On antibacterial activity of S. and other salazo-streptocides concede to initial sulfanamide drugs (see).
The page is well soaked up from went. - kish. path. It is metabolized
under the influence of azoreductases of hl. obr. in a liver and partially in intestines with formation of active metabolites — the sulfadimethoxine rendering antibacterial effect, and 5-aminosalicylic to - you, possessing the antiinflammatory and hyposensibilizing action. The page and its metabolites are brought out of an organism of hl. obr. with urine.
Pages apply to treatment of easy and medium-weight forms of nonspecific ulcer colitis in its active stage (see. Ulcer nonspecific colitis), and also for prevention of a recurrence of this disease.
In an acute stage of a disease drug is appointed inside the adult the I by 2 times a day (with a frequency of chair more than 5 times a day — on 0,5 g 4 times a day) during 3 — 4 weeks, then the daily dose is reduced to 1 — 1,5 g and continue treatment during 2 — 3 weeks. If necessary under close medical check increase in a daily dose up to 4 g is allowed (in four receptions).
To children in an initiation of treatment of S. appoint in the following daily doses: at the age of 3 — 5 years — 0,5 g, 5 — 8 years — 0,75 — 1 g, are more senior than 8 years — 1,5 g. On reaching therapeutic effect drug is cancelled, gradually reducing a daily dose for 1/4 each 10 — 14 days.
For prevention of palindromias of S. appoint adult 0,5 — 1 g a day within 2 — 6 months, then on 0,25 — 0,5 g within 6 — 12 months, to children — in the dose applied at the end of a course of treatment of an acute stage of a disease within 6 — 12 months.
S.'s use should be combined with other methods of treatment of nonspecific ulcer colitis (a diet, fortifying therapy, symptomatic means, etc.).
Side effect of drug is shown by allergic reactions, a leukopenia, dispeptic frustration, sometimes — decrease in a hemoglobin content.
To page it is contraindicated in the presence in the anamnesis of toksiko-allergic reactions to sulfanamide drugs and salicylates.
Form of release: tablets on 0,5 g. Storage: in well sealed package in the place protected from light.
Bibliography: New chemotherapeutic drugs for treatment of patients with infectious diseases, under the editorship of G. N. Pershin, page 207, M., 1976; Padey with to and I am E. N and P about l at x and - N and L. M. New sulphamide drugs of long action for treatment of infectious diseases, M., 1974.
E. N. Padeyskaya.