From Big Medical Encyclopedia

RETROLENTAL FIBROPLASIA (Latin retro back, behind + lens, lentis lentil, here — a crystalline lens; lat. fibra fiber + Greek plasis formation; synonym retinopathy of premature) — the bilateral disease of eyes, at Krom behind a crystalline lens is formed the dense connective tissue membrane soldered to an otsloyenny retina.

Develops preferential at premature children (see), been born with a weight (weighing) less than 1600 and respiratory disturbances. For the first time the disease is described in 1942 Mr. of Terry (T. L. Terry).

Main reason for R. f. pathogenic action of excess amount of oxygen at contents is premature in oxygen chambers. The opinion on possibility at the child after the birth of a relative hyperoxia is expressed when the pre-natal hypoxia was observed.

During R. f. distinguish 5 stages. In the first stage expansion and crimpiness of peripheral vessels of a retina, in the second — neovascularization of a retina, proliferation of connecting fabric on the course of its vessels is noted, the third stage is characterized by retinal apoplexies and a vitreous, growing of neogenic vessels and distribution of proliferative process to a vitreous. At the first and second stages there can occur the spontaneous regression of process which is expressed in a zapustevaniye of neogenic vessels of a retina. More often the disease progresses and passes into the fourth stage when as a result of education connective tissue tyazhy and shvart in a vitreous there comes partial amotio of a retina (see), going from an optic disk. Further, in the fifth stage, the retina exfoliates completely and together with connecting fabric forms behind a crystalline lens dense, gray color a membrane of various thickness. Fibrosis of a vitreous can be total. Sight goes down to a blindness. Changes of eyes at R. f. undergo a complete cycle of development within 4 — 6 months. In the subsequent normal growth can be late eyes (see), quite often develops iridocyclitis (see), cataract (see), secondary glaucoma (see).

R.'s treatment f. inefficiently. The forecast during the progressing of process heavy.

Prevention — the correct dosing of oxygen to premature children (see. Oxygen therapy ), antenatal protection of a fruit (see).

Bibliography: Katsnelson A. B. Anomalies of development and a disease of eyes at early children's age, JI., 1957, bibliogr.; Barr C. C., Rice T. And. and. Michels R. G. Angioma-like mass in a patient with retrolental fibroplasia, Amer. J. Ophthal., v. 89, p. 647, 1980; Fledelius H. Prematurity and the eye, Acta ophthal. (Kbh.), v. 128, suppl., p. 159, 1976; Kingham J. D. Acute retrolental fibroplasia, Arch. Ophthal., v. 95, p. 39, 1977; Terry T. L. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens, Amer. J. Ophthal., v. 25, p. 203, 1942.

A. V. Hvatova.