RETICULOSARCOMA (Latin reticulum grid + sarcoma; synonym: gistioblastny malignant lymphoma, malignant histiocytic lymphoma, retikulokletochny sarcoma, reticulocytoma, reticulosarcoma) — the malignant tumor developing from cells of a histiocytic row.
The term «reticulosarcoma» was offered in 1928 by Oberling (Ch. Oberling). In 1930. F. Roulet suggested to call these tumors reticulosarcomas. Was considered that a source of development of R. is the reticular macrophage (see. Reticular fabric ). Recently with the help immunol. methods of a research it was established that the vast majority of R. actually are lymphosarcomas (see).
Now R. diagnose extremely seldom, no more than in 3 — 4% of cases in relation to lymphosarcomas. Therefore there is no rather large number of observations of R. (in its modern representation), there are no authentic data about a wedge, R.'s current, life expectancy of patients and procedures of choice of treatment.
Differential diagnostic characters, only inherent R. and allowing to distinguish them from a lymphosarcoma, lymphogranulomatosis (see) and other tumors of the hemopoietic and adenoid tissue, do not exist. The diagnosis can be established only on the basis of studying of tumoral fabric, but also then the difficulties in diagnosis demanding special additional methods of a research meet: immunological, electronic and microscopic, cytochemical, etc.
Reliable morfol. criterion for R.'s identification are products tumor cells of the reticular fibers braiding separate cells in difference, e.g., from metastasises of undifferentiated cancer, at Krom these fibers surround group of tumor cells. More perspective for differential diagnosis are histochemical methods of a research (see), with the help to-rykh in tumor cells define higher activity nonspecific esterases (see), not inhibited sodium fluoride.
Consider that treatment of these tumors shall be intensive using complex chemotherapy and higher in comparison with lymphosarcomas of total exposure doses — 4500 — 5500 I am glad (45 — 55 Gr) at radiation therapy.
The forecast is adverse, however cases of a long bezretsidivny current of R. are described that formed the basis to consider R. potentially curable.
Bibliography: Carrhae I., etc. Limforetikulyarny diseases, the lane with English, M., 1980; Lymphoma of peripheral lymph nodes, under the editorship of D. I. Golovin, L., 1980; Pathoanatomical diagnosis of tumors of the person, under the editorship of N. A. Krayevsky, etc., page 384, M., 1982; Lennert K. Mohr i N. Malignant lymphomas other than Hodgkin's disease, B. — N. Y., 1977; Mathe G. Rappaport H. Histological and cy-tological typing of neoplastic diseases of haematopoietic and lymphoid tissues, Geneva, 1976; N g a n H. Jam esK. W. Clinical radiology of the lymphomas, But-terwarth, 1973; Oberling C. Les re-ticulosarcomes et les reticuloendotheliosar-comes de la moelle osseuse (sarcomes d’ Ewing), Bull. Ass. fran?. Cancer, t. 17, p. 259, 1928; R oulet F. Das primare Retothelsarkom der Lymphknoten, Virchows Arch. path. Anat., Bd 277, S. 15, 1930.
I. A. Yakovleva, A. I. Pavlovskaya.