From Big Medical Encyclopedia

QUATERONUM (Quateronum, GFH, joint venture. B) — ganglioblokiruyushchy means. альфа,бета-Диметил-гамма-диэтиламинопропилового n-butoksibenzoynoy ether of acid iodethoxide, C 22 H 38 NO 3 - I:

Powder, white with slightly yellowish shade, with a slight smell, bitter taste. Let's dissolve in water at weak heating, it is easily alcohol-soluble, it is very easy — in chloroform, it is almost insoluble on air.

To. weakens carrying out impulses in vegetative gangliya, blocks N-holinoretseptory of marrow of adrenal glands and sinocarotid balls, has coronarodilator effect, oppresses motor and secretory functions of a stomach. Unlike other ganglioblokiruyushchy means — petrolhexonium (see), Gangleronum (see), arpenal (see), To. not only does not reduce the maintenance of a free and general histamine in a gastric juice, and, on the contrary, considerably increases their quantity.

To. apply hl. obr. at a peptic ulcer, especially at localization of an ulcer in a bulb of a duodenum, and also at coronary insufficiency and an idiopathic hypertensia. Appoint inside in the form of tablets and water 0,6% of solution. At a peptic ulcer of a stomach accept on 0,02 — 0,03 g (1 tablet or 5 ml of 0,6% of solution) 3 — 4 times a day, a course of treatment of 3 — 4 weeks and more; for the prevention of attacks of stenocardia — in the beginning 0,01 g on reception, in 2 — 3 days increase a single dose to 0,02 g, accept 3 times a day, and at frequent attacks — 4 times a day during 3 — 4 weeks; at an idiopathic hypertensia appoint 0,03 g of 3 — 5 times a day, a course of treatment on average of 3 weeks the Highest doses for adults inside: one-time 0,05 g, daily 0,2 g.

At treatment by-effects can arise Quateronum: short-term headaches, dizziness, nausea, sometimes feeling of a raspiraniye in a thorax, at considerable overdose — locks. At patients with a peptic ulcer sometimes in the first days strengthening of pains in an anticardium and dyspepsia is noted. At patients with stenocardia attacks can become frequent; in these cases drug is cancelled for several days and then appointed in smaller doses; if by-effects do not stop, cancel drug.

Contraindications to use of drug are not revealed. It is necessary to be careful at appointment To. patient with hypotonia.

Forms of release: powder and tablets on 0,02 and 0,03 g. Storage: in well corked container protecting from effect of light.

See also Ganglioblokiruyushchy means .

Bibliography: Quateronum and experience of its clinical use, under the editorship of. A. L. Mndzhoya-na, Yerevan, 1966.

S. A. Mirzoyan.