QUANTUM BIOCHEMISTRY

From Big Medical Encyclopedia

QUANTUM BIOCHEMISTRY (synonym submolecular biology) — the section of biochemistry establishing connection between features of a structure and functioning of bioorganic molecules and fundamental laws of quantum mechanics. An object of research To. — analysis of communication of quantum-mechanical parameters of bioorganic molecules with features and evolution of a metabolism, problems of emergence of life, molecular bases of heredity { quantum genetics), molecular mechanisms of pathology and chemical pharmacology etc. The method of a research consists in carrying out calculations according to the theory of the molecular orbitals similar to calculations in quantum chemistry and giving quantitative characteristic of distribution and «mobility» of electrons that is directly connected with physical. - chemical properties of molecules and their activity.

Value K. for medicine it is connected with the analysis of submolecular mechanisms of a pathogeny, and also action pharm, drugs. The role of electronic charge on certain atoms for the speed of hydrolysis and cholinomimetic action of analogs of acetylcholine is established, «quantum-mechanical similarity» of nervous poisons to acetylcholine is shown. To one of examples can serve the interpretation at submolecular level of a structure and the mechanism of effect of carcinogens which allowed to open importance of size of energy, localization of electrons on certain atoms for this process and to replace biol, the Carcinogenicity test with carrying out chemical reaction with the osmium tetroxide which is strictly correlating with carcinogenic activity of connections. Quantum-mechanical approach gave also the chance to plan ways of a research of the mechanism of effect of carcinogens (see. Oncogenous substances ).

Ease of abiogenous emergence, the increased stability and reactivity of such substances as nitrogen bases (especially adenine), porphyrines and some other, is connected with delocalization of electrons in molecules of these connections. To. revealed a role of localization of electrons in active centers of enzymes, and also similarity of a structure of substrates of a number of hydrolases, a role of polymerases in processes of synthesis of DNA and RNA, etc.

See also Quantum biology .


Bibliography: Gladilin K. L. Quantum biochemistry, in book: Usp. biol, chemical, under the editorship of B. N. Stepanenko, t. 19, page 246, M., 1978; About l about in and N about in I. B., Piskunov A. K. and Sergeyev H. M. Elementary introduction to quantum biochemistry, M., 1969, bibliogr.; The Dewar M. D. S. Teoriya of molecular orbitals in organic chemistry, the lane with English, M., 1972; Ladik Ya. Quantum biochemistry for chemists and biologists, the lane with it., M., 1975, bibliogr.; Mack-blame R. and Sutcliffe B. T. Quantum mechanics of molecules, a per, with English, M., 1972; P yu l m and N B. and Pyulman And, Quantum biochemistry, the lane with English, M., 1965; Saint-György and And. Introduction to submolecular biology, the lane with English, M., 1964, bibliogr.; about N e, Bioelectronics, the lane with English, M., 1971, bibliogr.; Electronic aspects of biochemistry, ed. by B. Pullman, N. Y. — L., 1964; Molecular orbitals in chemistry, physics and biology, ed, by P. - the Lake of Lowdin a. B. Pullman, N. Y. — L., 1964.

K. L. Gladilin.

Яндекс.Метрика