PROSPIDINUM (Prospidinum; synonym Prospidii chloridum; joint venture. B) — the synthetic antineoplastic means relating to group of alkylating agents; N,N dichloride' - di (gamma chlorine - beta oxypropyl) - N', N- dispirotripiperazinit:
White crystal powder, easily water soluble. The mechanism of action is insufficiently studied; it is suggested about the membrane mechanism of its influence on tumor cells. After intravenous administration of P. and products of its turning into a current of 24 hours are brought out of an organism preferential with urine (80%).
Items apply at throat cancer, a papillomatosis of upper respiratory tracts, Kaposha's angiosarcoma, reticuloses of skin, including fungoid mycosis. Sensitivity to P. of a planocellular carcinoma cutaneum, cancer of a nasopharynx, ovaries is noted. Effect of drug in a complex with other chemotherapeutic cure for planocellular cancer of a lung is studied. In combination with radiation therapy of P. with success it is used at treatment of a retinoblastoma at children.
The drug is administered intravenously or intramusculary on 0,2 — 0,4 g, usually every other day or 2 times a week. Course dose of 2 — 6 g.
Unlike most of alkylating agents of P. has no the expressed effect on a hemopoiesis. At P.'s treatment paresthesias, changes in urine (a proteinuria, hyaline cylinders) and blood can be observed (the increased content of urea, creatinine, uric to - you, a hypopotassemia). Nausea and vomiting, stomatitis, alopecia, headache, dizziness, drowsiness, short-term loss of consciousness, rhinitis, dyskeratosis is in some cases possible. Due to the toxic action of P. on kidneys it is necessary to be careful at its inclusion in structure of medicinal complexes.
Form of release: the bottles containing 0,1 and 0,2 g of nonvolatile solid a cut just before introduction dissolve in isotonic solution of sodium chloride. Storage: in the dry cool place.
See also Antineoplastic means .
Bibliography: Perevodchikovan. I. Clinical chemotherapy of tumoral diseases, M., 1976; Prospidinum — new antineoplastic means, under the editorship of
V. A. Chernov, M., 1973.
N. I. Perevodchikova.