PROMERANUM (Promeranum; synonym: Chloromerodrinum, Chlormerodrin, Merilid, Neohydrin, Novohydrinum etc.; joint venture. And) — diuretic. 3-Hlorrtut-2-metoksipropilmochevina; With 5 H 11 O 2 N 2 HgCl:
White crystal powder or white crystals, slightly soluble in water and alcohol. Contains 54,6% of mercury.
Unlike mercusal (see) and other mercury diuretics P. apply inside. The diuretic effect at the same time develops for the 2nd day of treatment and reaches a maximum on 3 — the 4th day. After drug withdrawal the diuretic effect proceeds within several days.
Item. it is shown at an edematous syndrome at patients with a circulatory unefficiency, and also at damages of a liver. In modern medical practice of P. it is used seldom in view of availability of more effective and less toxic diuretics. Item, marked isotopes of mercury ( 197 Hg or 203 Hg), finds application for a radio isotope research of function of kidneys. Appoint inside on 1 tablet after food 3 — 4 times a day. In need of the first days of treatment it is possible to accept up to 4 — 8 tablets a day. On reaching therapeutic effect the dose is reduced.
The highest doses for adults: one-time 0,036 g (2 tablets), daily 0,144 g (8 tablets).
At P.'s use dispeptic frustration, a headache, a skin itch and other complications characteristic of mercury diuretics are possible. Drug is contraindicated at acute and hron. nephrites, nephrosclerosis, renal failure.
Form of release: tablets on 0,0183 g. Storage: in the place protected from light.
See also Diuretics .
Bibliography: Berkhin E. B. Diuretics, M., 1967; Clinical pharmacology, under the editorship of V. V. Zakusov, page 275, M., 1978; Lebedev A. A. and Kantariya V. A. Diuretics, Kuibyshev, 1976; Mashkovsky M. D. Pharmaceuticals, p.1, page 438, M., 1978; The pharmacological basis of therapeutics, ed. by L. S. Goodman a. A. Gilman, N. Y., 1980.
A. A. Lebedev.