POTASSIUM PERCHLORATE

From Big Medical Encyclopedia

POTASSIUM PERCHLORATE (Kalii perchloridum; synonym Chlorigene; joint venture. B) — anti-thyroid means, potassium salt chloric to - you, KClO 4 .

To. the item — inodorous white crystal matter, slaborastvorimy in water, not alcohol-soluble. Thyreostatic effect To. the item is based on blocking of capture of iodine by a thyroid gland. It is applied sometimes at an easy form of a diffusion toxic craw; at the same time control is necessary gematol. Drug is appointed inside before food. At an easy form of a disease the daily dose in the first 4 — 6 weeks usually makes 0,5 — 0,75 g, then 0,25 g a day; duration of treatment is 2 — 4 months.

Use To. to the item in a wedge, practice it is limited in connection with its considerable side effect, the most serious of which — aplastic anemia and an agranulocytosis (are observed seldom at reception of high doses); skin allergic reactions, a headache, the dispeptic phenomena are often noted.

Contraindications: pregnancy, peptic ulcer, diseases of the hemopoietic bodies.

Forms of release: powder and tablets on 0,25 mg. Store with precaution in usual conditions.

See also Anti-thyroid means .

Bibliography: The guide to clinical endocrinology, under the editorship of V. G. Baranov, L., 1977; Means J. Stanbury J. Diseases of thyroid, gland, L., 1968.

M. D. Donskova.

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