PIROLLIZIDINA — The oncogenous vegetable matters relating to alkaloids.
Items contain in various plants, their greatest concentration is noted in seeds, flowers and roots. It is known apprx. 100 pirollizi-din and their N-oxides.
Oncogenous action of P. is studied in experimental conditions — tumors are induced at rats and chickens. At rats under the influence of P. tumors of hl develop. obr. a liver, is more rare — went. - kish. path, head and spinal cord, pancreas. In P.'s organism are exposed to metabolic transformations under the influence of enzymes of a cytoplasmic reticulum. Except oncogenous action, P. have the expressed toxic influence on many animal species; so, DL 50 the most toxic of P. — the retrorsina — makes 35 mg on 1 kg of the weight (weight) of a body. Under the influence of P. at animals arteritis, hypertensia, necroses of a liver, a fluid lungs develop. Fulvin has embriotoksichesky and teratogenic effect on rats, mutagen action on drosophilas, causes aberation chromosomes.
For P.'s definition use methods chromatography (see).
See also Oncogenous substances .
Bibliography: Rubenchik B. L. Food, carcinogens and cancer, Kiev, 1979; S with h about e n t and 1 B. of Carcinogens in plants and microorganisms, in book: Chemical carcinogens, ed. by of Page E. Searle, p. 626, Washington, 1976, bibliogr.
V. S. Turusov.