PHENOQUIN (Cinchophenum; synonym: quinophan, Aciphen, Cinchophan, Urosol, etc.; joint venture. B) — protivopodagriche-sky means. 2-Feniltsinkhonino-vaya to - that; >S16NP]Yu2.
Yellowish powder, water-insoluble, a little soluble in divorced to-takh, easily soluble in divorced solutions of caustic alkalis and sodium carbonate.
Increases release of uric acid (see) from an organism, promoting its transition from fabric depots to blood and strengthening its renal elimination. It is supposed also that C. can oppress several biosynthesis uric to - you. Renders moderately expressed analgetic, antiinflammatory and febrifugal action. Stimulates secretion of a gastric juice and bile.
It is well soaked up from went. - kish. path. It is metabolized in a liver with formation of an active metabolite (oxyquinophan), to-rogo connect influence of C with action. on allocation uric to - you and other its effects.
Earlier drug was used for stopping of bad attacks and treatment hron. gouts (see), appointing him inside the adult on 0,25 — 0,5 g to reception 3 — 4 times a day against the background of plentiful alkaline drink. However it turned out that at its prolonged use development of heavy atrophic changes of a liver is possible. To K'Roma of that, C. renders the expressed irritant action on a mucous membrane went. - kish. a path and in this regard causes the phenomena of gastritis and dispepsichesky frustration. In modern medical practice it is almost not used since by efficiency concedes to other protivopodagri-chesky means, and surpasses them in toxicity.
It is contraindicated at diseases of a liver and kidneys, a peptic ulcer of a stomach and a duodenum, bronchial asthma.
Form of release: tablets on 0,5 g. Storage: in
the place protected from light.
See also P rotivo gouty means. V. K. Muratov.