FENILYN (Phenylinum; synonym: Athrombon, Danilone, Emandione, Fenilin, «Hedulin, Phenindionum, Phenylindandionum, P. J. D., Pin-dione, Thrombophen, Thrombantin, Trombosol, etc.; GFH, cn. A) — anticoagulant of indirect action. 2-Fenilindandion-1,3; C15H10O2:
White or creamy-white crystals. We will dissolve in water very little, we will dissolve in 95% alcohol a little; * °pl 1^8 — 151 °; pier. the weight (weight) 222,24 Solutions have coloring from orange to orange-red.
Like other anticoagulants of indirect action (see Anticoagulants) Phenilinum reduces coagulability of blood only in an organism. It is an antimetabolite of phthiocol and in this regard oppresses in a liver biosynthesis of blood-coagulation factors II (prothrombin), VII (proconvertin), IX (anti-haemo-filny globulin B), X (a Stuart factor — P pay Ayr). Decrease in concentration of these factors in a blood plasma comes in 8 — 10 hours after reception F., and the maximum effect develops in 24 — 30 hours and is gradually weakened within several days. Kumuliruyet more than neodicoumarin, and on this ability is close to a nitrofarin and Syncumarum (see. And prices to an eye of Mar ol).
It is quickly and fully soaked up from went. - kish. path. In the maximum concentration collects in blood in 1 — 3 hour after intake. Rather quickly disappears from a blood plasma, collecting hl. obr. in a liver and to a lesser extent in intestines and lungs. It is partially deposited in erythrocytes. Elimination half-life F. makes of blood apprx. the 5th hour. At prolonged use can cause coloring of palms in orange color in nek-ry patients and urine — in pink that is explained by transformation F. in an organism in an enol form also does not constitute danger. Speed of metabolism F. at the person is lower in comparison with neodicoumarin (see). Big fluctuations of speed of biotransformation F are noted. at various patients. It is removed through kidneys preferential in the form of metabolites.
Like other anticoagulants of indirect action F. apply to long decrease in coagulability of blood for the purpose of the prevention and treatment of tromboembolic episodes.
In the 1st day F. appoint inside the adult usually in a daily dose 0,12 — 0,18 g (in 3 — 4 receptions), to the 2nd day — in a daily dose of 0,09 — 0,15 g, in the next days — in so-called maintenance doses, to-rye make from 0,03 to 0,06 g a day. The dose is korrigirut according to indicators of a blood coagulation. As optimum therapeutic level of decrease in hemocoagulation it is recognized such, at Krom the tromboplasti-modern times on Kvika are extended by 2 — 2,5 times that corresponds to indicators of a prothrombin ratio within 40 — 50%. For long decrease in coagulability of blood for prevention of thromboses F. appoint 0,03 g of 1 — 2 time a day. In acute cases of thrombosis in the first day treatment F. combine with purpose of heparin (see).
The highest doses for adults inside: one-time 0,05 g, daily 0,2 g, Phenilinum derkhmati-that can cause allergic reactions in a look, temperature increase, a diarrhea, vomiting, development of hepatitis, oppression of a hemopoiesis.
In order to avoid overdose at treatment F. along with control of coagulability of blood the research of urine for identification of a possible hamaturia is reasonable. At overdose reduce a dose or cancel anticoagulant. Specific antagonist F. vitamin of Kh is.
It is contraindicated in the same cases, as other anticoagulants (at the lowered coagulability of blood, pregnancy, stomach ulcer and a duodenum, etc.).
Form of release: powder, tablets on 0,03 g. Storage: powder — in well corked container protecting from effect of light, a tablet — in the place protected from light.
Bibliography: Urgent problems haemo -
staziologiya, under the editorship of V. V. Petrovsky, etc., page 430, M., 1981; L yu with about in V. A., Belousov Yu. B. and Bokarev I. N. Treatment of thromboses and hemorrhages in clinic of internal diseases, M., 1976; Malinovsky H. N
and Kozlov V. A. Anticoagulating and thrombolytic therapy in surgery, M., 1976; Chazov E. I. and L and -
to and K. M N. Anticoagulants and fibri-nolktichesky means, M., 1977.
K. M. Lakin.