PARMIDINUM (Parmidinum ; synonym: Prodectinum, Anginin, Prodectin, Pyridinolcarbamatum etc.) — anti-atherosclerotic means. Encore-N-Metilkarbaminovy ether 2,6 pyridines of pyridine; With 11 H 15 N 3 O 4 :
White or almost white crystal powder, slightly soluble in water and almost insoluble in alcohol.
In P.'s experiment prevents development of atherosclerotic changes in vessels and causes a rassasyvaniye of the atheromatous centers in a vascular wall, and also partial substitution by their smooth muscle cells. On various models P. the selective anti-sconce has dikinin effect, has the expressed antiinflammatory (anti-exudative) activity. Besides, it reduces aggregation of thrombocytes and lowers coagulability of blood a little.
According to a wedge, to observations at the patients suffering from vascular diseases of atherosclerotic genesis, P. improves microcirculation and blood circulation in the vessels struck with atherosclerotic process and reduces its expressiveness.
Mechanism of action The item at vascular defeats of the atherosclerotic nature is caused by hl. obr. its antibradikininovy properties: The item prevents the changes of a vascular wall (wrinkling of endothelial cells, increase in interendothelial spaces, increase in permeability, etc.) caused by bradikinin and promoting development of atherosclerotic process, i.e. penetration into a vascular wall of lipids, proteins and enzymes, adjournment in it atheromatous substances, to fatty degeneration and formation of the centers of a necrosis.
The item is well soaked up from went. - kish. a path, it is metabolized in a liver and brought out of an organism with urine in the form of a demetilirovanny metabolite and partially — in not changed look.
Elimination half-life of drug from 5 to 12 hours
of the Item. apply at atherosclerotic diseases of vessels of a brain, heart, extremities, an atherosclerotic and diabetic retinopathy, a vein thrombosis of a retina, an obliterating endarteritis, an aortic arch syndrome, and also at trophic ulcers of extremities. Besides, P. is effective at diabetic nefropatiya and exerts beneficial effect on a condition of a stomach and a pancreas at patients with a diabetes mellitus.
Items appoint inside 0,25 g 3 — 4 times a day, if necessary increasing a single dose to 0,75 g. Average daily doses of 1 — 2 g. Duration of a course of treatment is from 2 to 6 months and more.
Side effect The item is shown by nausea, a headache and skin allergic reactions (erythema), to-rye quickly pass at a dose decline or drug withdrawal.
There are no contraindications to P.'s use.
Form of release: tablets on 0,25 g. Keep in the place protected from light.
Bibliography: Chazov E. I. Debatable questions of use of some methods of treatment of cardiovascular diseases, Rubbed. arkh., t. 47, No. 5, page 33, 1975; Schwartz G. Ja. Parmidinum — new anti-atherosclerotic and antiinflammatory drug, Chemical - pharm, zhurn., t. And, No. I, page 139, 1977, bibliogr.
V. K. Muratov.