PANCREATINUM (Pancreatinum) — fermental drug from pancreases of the lethal cattle. Contains the main enzymes of a pancreas, hl. obr. trypsin and amylase.
Yellowish powder with a specific smell of the dried-up animal fabrics. Let's badly dissolve in water, it is insoluble in alcohol and other organic solvents.
It is standardized biol. by method on ability to split casein trypsin and to hydrolyze starch amylase. In 1 g of P. — 25 PIECES. The major component P. is trypsin (see), to-ry in a small intestine splits proteins to amino acids. Amylase (see) hydrolyzes starch. P.'s activity is shown only in the conditions of the alkalescent environment of a small intestine provided with the hydrosodium carbonate which is contained in intestinal and pancreatic juice. In a stomach under the influence of salt to - you drug can partially be inactivated.
Items apply at insufficiency of vneshnesekretorny function of a pancreas (at hron, pancreatitis, tumors or an atrophy of a pancreas), the digestive disturbances connected with diseases of a liver, a gastric akhiliya, anacid and subacid gastritises, hron, enterita and coloenterites. The item is appointed sometimes for improvement of digestion of food after operative measures on went. - kish. a path and for preliminary peptonization of food in cases of disturbance of digestive function went. - kish. path.
Items accept inside to food in the form of powder, tablets or capsular. For prevention of destruction of drug salt to - that a gastric juice should wash down it with alkaline mineral waters or 7% solution of hydrosodium carbonate. By adult P. appoint 0,5 —-1,0 g to reception 3 times a day. If necessary the dosage can be increased. To children, depending on age, drug appoint in doses from 0,1 to 0,5 g to reception.
Forms of release: powder and tablets on 0,5 g. Keep in well corked container in the dry cool place.
Pancreatic enzymes are also a part of many complex fermental drugs used at diseases went. - kish. a path, napr, a panzinorma a fortea of festal, Mexasums, etc.
See also Fermental drugs .
Bibliography: Radoil O. S. Pharmacological bases of treatment of diseases of digestive organs, page 81, M., 1976.
N. V. Korobov.