OSTEOPOIKILOSIS

From Big Medical Encyclopedia

OSTEOPOIKILOSIS (grech, osteon bone + poikilos motley, spotty; synonym: the inborn scattered sclerosing, or condensing osteopathy, inborn spotty multiple osteopathy) — an inborn general disease of a skeleton with education in many bones of more or less densely located homogeneous centers of a sclerosis. The lake is one of manifestations osteodysplasias (see).

The island for the first time described in 1905 Mr. A. Stieda, later, in 1907, H. E. Albers-Schon-berg and in 1916 Ledu-Lebar (r. Ledoux-Lebard) with sotr.

Roentgenogram of brushes sick osteopoikilosis: damages of metacarpal bones and phalanxes are specified by shooters.

The greatest number of the centers of a sclerosis arises in an epiphysis of bones. In a diaphysis the centers meet very seldom. Most often bones of a wrist, metacarpal bones and phalanxes (fig.), from long tubular bones — humeral and femoral bones are surprised. Lumbar and sacral vertebrae are surprised more often than cervical and chest. At damage of shovels and a basin most densely the centers are located near joint departments of bones. Sometimes the centers adjoin subchondral plates of joint surfaces of bones. Outlines of the centers accurate and equal, sometimes, especially at poles, they with jags. The form and the sizes of bones do not change. Periosteal reaction is absent. Despite a close arrangement of the centers to the joint surface of bones, reaction from joints (e.g., in the form of a synovitis) does not happen. Patol, changes and an ozlokachestvleniye at O. is not observed. In process of growth of a skeleton the centers slowly increase in sizes and quantity. Gistol, researches K. Sh the pestilence of la was shown that these centers consist of densely located bone crossbeams of a lamellar structure, to-rye are concentrated on certain sites and without sharp borders pass into correctly oriented bone structures.

The lake — a rare disease; it is found at any age, is slightly more often at men. Cases of so-called family diseases, including in different generations are known. During human life O.'s centers do not disappear. A wedge, manifestations are absent. Content of calcium, phosphorus, an alkaline phosphatase in blood serum is not changed. In nek-ry cases of O. it can be combined with lentikulyarny disseminated dermatofibrozy (see. lentikulyarny disseminated ) and palmar and bottom hyperkeratosis (see).

As a rule, O. is distinguished accidentally at rentgenol, the research made in other occasion. Find multiple damage of bones of a skeleton, generally in epiphyseal zones. Bilateral defeat is noted, but changes are not always expressed symmetrically. The struck departments of bones on the roentgenogram have a characteristic spotty, skewbald appearance. The centers of a rounded or oval shape with a diameter up to 0,5 — 1,0 cm; they can be located both is rare, and is dense. In some cases O. happens macrofocal, sometimes the small and large centers are combined with polosovidny sites of consolidation. Bigger diameter of the centers usually matches the direction of load of a bone.

At children's age of O. it is necessary to differentiate with an inborn epiphyseal dot bone dysplasia (see. Ferbank disease ), adults — with metastasises have tumors. At the last the centers have various form, usually indistinct, greased outlines, they are localized in different departments of bones; the tendency to their arrangement near joint departments of bones and of the course of power lines of loadings is not observed.

Treatments at O. it is not required. Forecast in all cases favorable.



Bibliography: Bartusevichene A. S. and Vitenas A. M. Rare forms of an osteopoikilosis, Vestn, rentgenol, and radio-gramophones., No. 3, page 81, 1978; To and l e-the II ying N. I. and Afanasenko P. T. Rare observation of an osteopoikilosis, Zdra-vookhr. Belarus, No. 8, page 79, 1973; Lavrushenkova 3. A. K to a question of an osteopoikilosis, Vestn, rentgenol, pi of radio-gramophones., No. 3, page 80, 1978; Fly N - e r of S. A. Radiodiagnosis of diseases of bones and joints, book 1, page 451, M., 1964; Claus H. G. Die Osteopoi-kilie, Handb, d. med. Radiol., hrsg. v. L. Diethelm u. a., Bd 5, T. 3, S. 182, Accusative of a., 1968; S with h m about of 1 G. Anato-misclie Befunde bei einem Falle von Osteo-poikilie, Fortschr. Rontgenstr., Bd 44, S. 1, 1931; Stieda A. Uber umschrie-bene Knochenverdichtungen im Bereieh der Substantia spongiosa im Rontgenbilde, Brim's Beitr. klin. Chir., Bd 45, S. 700, 1905.


M of K. Klimova.

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