NITROSORBIDUM (Nitrosorbidum; synonym: Carvasin, Isorbid, Isosorhide Dinitrate, Isosorbidi, Dinitras, Rigerial, Risordan etc.) — anti-anginal means. 1,4; 3, b-Diangidro-D-sorbita dinitrate; With 6 H 8 N 2 O 8 :
White fine-crystalline powder. It is almost water-insoluble, almost insoluble in alcohol.
On the nature of influence on coronary circulation and the mechanism of action of N. it is close to to nitroglycerine (see) and to other organic nitrates (expands vessels owing to spasmolytic action, influences the central regulation of blood circulation and suppresses cardiovascular components of «primary» pain). Due to the slow absorption of N. from went. - kish. a path the anti-anginal effect develops gradually and after a single dose proceeds during 3,5 — 5 hours that is caused probably by strong linkng of N. with serum proteins.
Apply for the prevention of attacks of stenocardia at hron, coronary heart disease. The N can be applied also at the diseases which are followed by spasms of peripheral vessels (an endarteritis, etc.).
Appoint inside on 0,005 — 0,01 g on reception 2 — 3 times a day courses for 10 — 20 days. If necessary courses of treatment are repeated.
In quality by-effects The N can cause a headache, dizziness, nausea, decrease in the ABP. Nitroglycerine is contraindicated in the same cases, as (the increased intracranial pressure, a hematencephalon, etc.). At an acute myocardial infarction of N. apply with care (under control of the ABP).
Form of release: tablets on 0,005 and 0,01 g. Keep in the cool, protected from light place.
See also Anti-anginal means .
Bibliography: Clinical pharmacology, under the editorship of V. V. Zakusov, page 196, M., 1978.
E. A. Bendikov.