From Big Medical Encyclopedia

MUCOUS DYSTROPHY (Greek dys-+ trophe food; synonym colloid dystrophy) — the disturbance of exchange of glycoproteins which is characterized by accumulation of slime (mucin) and muciform connections (pseudomucins or mucoids) in epithelial cells or the main substance of connecting fabric and its derivatives (a cartilaginous and bone tissue).

On preferential localization of dystrophic changes in a cell or interstitial substance distinguish respectively parenchymatous and mesenchymal S. of. Parenchymatous mucous dystrophy is connected with disturbance of education and allocation slime (see) epithelial cells that can be shown by accumulation mucin (see) in cells. Intracellular accumulation of slime can be followed by desquamation of epithelial cells and their necrosis. Often parenchymatous mucous dystrophy is a compound component catarral inflammations (see). Hyperproduction of slime and the related mucous dystrophy are observed at implantation of muciparous cells on a peritoneum (see. Pseudomyxoma ), napr, as a result of perforation of a worm-shaped shoot - at myxoglobulosis (see). Mucous dystrophy often develops in epithelial tumors, especially it is characteristic of mucous cancer (see), cells to-rogo due to accumulation of slime in cytoplasm get a cricoid form. Parenchymatous S. of is the cornerstone of a pathogeny mucoviscidosis (see), at Krom morfol. changes in internals are connected with change physical. - chemical properties of a secret of all excretory glands. The raised products of slime can be observed also in fiziol. conditions, napr, at impact of cold on a mucous membrane of upper respiratory tracts, at irritation of a stomach food masses. Unlike parenchymatous mucous dystrophy at these states at there is no expressed desquamation of an epithelium.

Physical. - chemical properties of slime at parenchymatous S. are extremely various. Sometimes it dense also forms traffic jams (e.g., at bronchial asthma), to-rye obturirut output channels of glands of a mucous membrane of respiratory tracts, leading to development of retentsionny cysts. During the closing of output openings of adnexal bosoms of a nose develops mucocele (see). The pseudomucins collecting in ferruterous structures can be condensed and take a form of a colloid. In such cases speak about colloid dystrophy, to-ruyu find, e.g., in a thyroid gland at a colloid craw. The outcome of parenchymatous mucous dystrophy depends on degree and duration of the raised slizeobrazovaniye. The epithelium can be exposed to an atrophy or regenerate.

At mesenchymal S. of in interstitial fabric muciform substances from group collect glycoproteins (see), among to-rykh find hyaluronic and chondroitinsulphuric to - you. Such sliming of fabrics can be local or the general. Local mesenchymal S. is most often observed by in tumors from connecting (fibroma, a lipoma, a myxoma, a myxosarcoma), cartilaginous (chondroma) and bone (osteoma) of fabrics. Similar changes are noted in a stroma of epithelial tumors, at a nek-ry dermatosis (a nodular myxedema, a scleromyxedema, a follicular mucinosis). The general mesenchymal S. is observed by at hypofunction of a thyroid gland (see. Hypothyroidism ). Unlike mucoid dystrophy at mesenchymal S. of fabric has a characteristic osliznenny appearance that is probably caused by qualitative and quantitative distinctions of the substances collecting in the main substance. Mucoid swelling is morfol. manifestation of superficial disorganization of connecting fabric, in the main substance a cut collects and redistributes glikozaminoglikana, at the same time fibrous structures suffer slightly (see. Proteinaceous dystrophy) . The complete recovery of structure of fabric can be the result of mucoid swelling. During the progressing of disorganization of connecting fabric transition of mucoid swelling to fibrinoid changes is noted, and at mesenchymal mucous dystrophy of it does not happen.

See also Dystrophy of cells and fabrics .

Bibliography: Davydovsky I. V. General pathology of the person, page 85, M., 1969; Pathoanatomical диагностика^ tumors of the person, under the editorship of N. A. Krayev-skogoidr., page 171, etc., M., 1982; With t r at-to about in A. I. and Serov V. V. Pathological anatomy, page 26, M., 1979; Robbins S. L. a. Cotran R. S. Pathologic basis of disease, Philadelphia a.o., 1974.

S. P. Lebedev.