MIDANTANUM (Midantanum; synonym: Adamantin, Amantadine hydrochloride, Amantadini Hydrochloridum, Mantadix, Diamantanamin, Mydantan, Paramantin, Protexin, Symmetrel, Virofral, Yeregit etc., joint venture. B) — protivoparkinsonichesky medicine. Steady synthetic primary amine with three-ring chemical structure: 1 aminotricyclodean hydrochloride, C 10 H 17 N-HCl:
Colourless octahedral crystals with a light smell of camphor; let's well dissolve in water and alcohol. Drug is well soaked up and quickly it is found in blood, urine, and also in lungs, a liver and kidneys. In a liver and M.'s kidneys collects in the concentration exceeding its content in urine. It is removed with urine (to 90% of the entered dose).
In 1964 M. was offered as antiviral means by Davis (Davies), etc. (USA). It had virusostatichesky effect on an influenza virus of type A in culture of fabric, chicken embryos and in an organism a lab. animals; a certain preventive efficiency at flu A2 was established and at people. However in connection with possible by-effects of M. did not find broad application as anti-influenza means. Remantadinum was more effective anti-influenza drug — derivative
M. V the subsequent the therapeutic effectiveness of M. at parkinsonism was found, and he took the place among protivoparkinsonichesky means (see), influencing dofaminergichesky systems of a brain. The mechanism of action of M. comes down to stimulation of release of dopamine from neyronalny depots and to sensitization of dofaminergichesky receptors to this mediator that contributes to normalization neyrofiziol. processes in basal gangliya. There are also data that M. slows down generation of impulses in motor neurons of c. N of page.
Apply M at Parkinson's disease and parkinsonism of various etiology. The greatest therapeutic effect is noted concerning an akinetiko-rigid syndrome, its influence on a hyperkinetic syndrome (tremor) is considerably less expressed. The effect is, as a rule, observed in the very first days of treatment. Appoint M. inside after food. Initial doses of 0,05 — 0,1 g 2 times a day, then 3 — 4 times a day. Daily doses of 0,2 — 0,4 g. Duration of a course of treatment is 2 — 4 months. The dose in 0,4 g can make sick, vomiting, the general weakness, headaches, sleeplessness, dizziness, the dispepsichesky phenomena, hypostases in an ankle joint.
The m can be applied in combination with other protivoparkinsonichesky drugs (cholinolytics and L-dofa).
It is contraindicated M at acute and hron, diseases of a liver and kidneys, and also at pregnancy. With care it should be applied the patient with mental diseases, at a thyrotoxicosis and epilepsy.
Form of release: tablets, coated, on 0,1 g. In packaging of 50 and 100 pieces.
Storage in the dry place.
Bibliography: O. A. boulders, etc. About use of domestic drug of Midantanum at treatment of a parkinsonichesky syndrome, Zhurn, a neuropath, and psikhiat., t. 74, No. 8, page 1178, 1974, bibliogr.; Flu of A2 Hong Kong, under the editorship of D. M. Zlydniko-va, L., 1971; To and m I am a N about in I. M., Buy with to A. G. and To and c of e of N And. 3. Experience of use of Midantanum for treatment and prevention of an antipsychotic syndrome, Zhurn, a neuropath, and psikhiat., t. 73, No. 8, with 1218, 1973, bibliogr.; Mashkovsky M. D. Pharmaceuticals, p.1, page 154, p. 2, page 318, M., 1977.
I. G. Balangding.