METOKSIFLURAN (Methoxyfluranum; synonym: Inhalanum, Penthranum, Inhalanum, Methoxyflurane, Penthrane etc.; joint venture. B) — means for an inhalation anesthesia. 2,2-Dikhlor-1,1-diftoretilmetilovy ether; With 3 H 4 Cl 2 F 2 O:
Colorless transparent volatile liquid with a fruit smell; pier. weight 164,97, t ° kip apprx. 105 °, plotn. 1,42 at t ° 25 °. Evaporates a little (partial pressure of a saturated steam at t ° 20 ° equally to 25 mm of mercury.). M.'s vapors of in mix with air and oxygen in narcotic concentration do not ignite and do not explode. It is well liposoluble (a distribution coefficient oil/water 400).
In subnarcotic concentration (to 0,8 about. the %) M. causes an analgesia, in higher — a deep anesthesia. Induction in an anesthesia is long (15 — 20 min.) since saturation of fabrics M. happens slowly.
Stages anesthesia (see) are expressed indistinctly, eye symptoms are absent. Excitement is expressed, several minutes last. Muscular relaxation is proportional to depth of an anesthesia. Awakening after an anesthesia comes in 15 — 60 min., and the analgesia and a postanesthetic depression remain during 2 — 3 hours after awakening owing to slow allocation of M. from an organism. Apprx. 50% of M. it is allocated in not changed look, other part is metabolized and removed in the form of fluorides, oxalates, and also the fluorinated and chlorinated derivatives acetic to - you.
M use for the general anesthesia at many operative measures. Due to the expressed analgetic action of M. it is also possible to apply in concentration 0,4 — 0,5 about. % for an autoanalgeziya in obstetrics and traumatology (at burns).
It is recommended to apply M. in a half-closed contour with specially calibrated evaporator out of a circulating system. Initial concentration at M.'s anesthesia — 1,5 — 2 about. %, supporting — 0,5 — 0,8 about. %. However in connection with long induction of M. usually use with an introduction intravenous anesthesia (e.g., barbituric) and in mix with nitrous oxide (see) or Ftorotanum (see). During an anesthesia of M, the ABP lowers by 10 — 15%; the tone of vessels and the general peripheric resistance at the same time do not change or slightly decrease; contractility of a myocardium, shock and minute volumes of heart decrease. Quite often there is a sinus bradycardia, edges is eliminated with atropine. The m moderately oppresses breath in this connection development respiratory is possible acidosis (see). After a long anesthesia of M. there can be a polyuria and dehydration (see. Dehydration of an organism ) as a result of damage of kidneys fluorides.
The m sensibilizes a myocardium to catecholamines and exponentiates action of the anti-depolarizing muscle relaxants.
At disturbance of functions of a liver and kidneys, and also at a hyperadrenalemia (e.g., at a pheochromocytoma) M. needs to be applied with care.
Produce in bottles of dark glass 50 ml with addition of preservative (0,01% of buthylhydroxytoluene). Keep in densely closed bottles in the cool place.
Bibliography: The guide to anesthesiology, under the editorship of T. M. Darbinyan, page 11, etc., M., 1973; The pharmacological basis of therapeutics, ed. by L. S. Goodman a. A. Gilman, p. 89, N. Y. — L., 1975.
O. Yu. Uryupov.